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Table 1 Odds ratios (OR) and 95% confidence interval (95CI) for genotypes studied among healthy controls and patients with ankylosing spondylitis (AS)

From: Genetically determined high activities of the TNF-alpha, IL23/IL17, and NFkB pathways were associated with increased risk of ankylosing spondylitis

Gene

rs-number

Healthy controls

AS

Unadjusted

Adjusted, age & sex

Adjusted, age, sex & smoking

OR (95 CI)

p

OR (9 5CI)

p

OR (95 CI)

p

TLR1

rs4833095

 TT

485

415

      

 TC

261

238

1.07 (0.86–1.33)

0.57

1.03 (0.82–1.29)

0.83

1.05 (0.78–1.42)

0.73

 CC

20

43

2.51 (1.45–4.34)

0.00095

2.59 (1.48–4.51)

0.00081

2.86 (1.44–5.68)

0.0026

 TC or CC

281

281

1.17 (0.95–1.44)

0.15

1.14 (0.91–1.41)

0.25

1.18 (0.89–1.58)

0.26

TLR2

rs3804099

 TT

241

197

      

 TC

393

354

1.10 (0.87–1.40)

0.42

1.07 (0.84–1.37)

0.58

1.02 (0.73–1.42)

0.90

 CC

144

142

1.21 (0.89–1.63)

0.22

1.24 (0.91–1.68)

0.17

1.30 (0.87–1.96)

0.20

 TC or CC

537

496

1.13 (0.90–1.41)

0.29

1.11 (0.89–1.40)

0.36

1.10 (0.80–1.50)

0.57

TLR2

rs11938228

 CC

327

314

      

 CA

368

313

0.89 (0.71–1.10)

0.27

0.86 (0.69–1.07)

0.17

0.80 (0.60–1.08)

0.15

 AA

76

69

0.95 (0.66–1.36)

0.76

0.92 (0.63–1.33)

0.66

1.03 (0.62–1.69)

0.92

 CA or AA

444

382

0.90 (0.73–1.10)

0.30

0.87 (0.70–1.07)

0.19

0.84 (0.63–1.11)

0.22

TLR2

rs4696480

 AA

199

179

      

 AT

417

348

0.93 (0.72–1.19)

0.55

0.89 (0.69–1.15)

0.38

0.84 (0.60–1.18)

0.31

 TT

155

169

1.21 (0.90–1.63)

0.20

1.16 (0.86–1.58)

0.33

1.18 (0.78–1.78)

0.44

 AT or TT

572

517

1.00 (0.79–1.27)

0.97

0.97 (0.76–1.23)

0.78

0.92 (0.67–1.27)

0.62

TLR4

rs5030728

 GG

359

322

      

 GA

323

298

1.03 (0.83–1.28)

0.80

1.01 (0.81–1.27)

0.91

0.93 (0.69–1.25)

0.62

 AA

78

70

1.00 (0.70–1.43)

1.00

0.98 (0.68–1.42)

0.93

0.87 (0.53–1.42)

0.57

 GA or AA

401

368

1.02 (0.83–1.26)

0.83

1.01 (0.82–1.25)

0.94

0.91 (0.69–1.21)

0.53

TLR4

rs1554973

 TT

440

395

      

 TC

272

261

1.07 (0.86–1.33)

0.55

1.06 (0.85–1.32)

0.62

0.98 (0.73–1.32)

0.90

 CC

62

33

0.59 (0.38–0.92)

0.02

0.55 (0.34–0.86)

0.01

0.68 (0.38–1.23)

0.20

 TC or CC

334

294

0.98 (0.80–1.21)

0.85

0.96 (0.78–1.19)

0.72

0.93 (0.70–1.24)

0.63

TLR4

rs12377632

 TT

306

271

      

 TC

358

319

1.01 (0.81–1.26)

0.96

1.05 (0.84–1.32)

0.66

1.07 (0.78–1.46)

0.67

 CC

102

96

1.06 (0.77–1.47)

0.71

1.11 (0.80–1.55)

0.52

1.41 (0.92–2.17)

0.12

 TC or CC

460

415

1.02 (0.83–1.26)

0.86

1.06 (0.86–1.32)

0.58

1.14 (0.85–1.53)

0.37

TLR5

rs5744168

 CC

672

605

      

 CT

94

89

1.05 (0.77–1.43)

0.75

1.05 (0.77–1.45)

0.74

0.89 (0.58–1.37)

0.60

 TT

5

2

0.44 (0.09–2.30)

0.33

0.45 (0.08–2.43)

0.35

0.04 (0.00–3.54)

0.16

 CT or TT

99

91

1.02 (0.75–1.39)

0.89

1.02 (0.75–1.40)

0.88

0.84 (0.55–1.29)

0.43

TLR5

rs5744174

 TT

215

216

      

 TC

399

337

0.84 (0.66–1.07)

0.15

0.85 (0.67–1.09)

0.20

0.82 (0.60–1.14)

0.24

 CC

144

138

0.95 (0.71–1.29)

0.76

1.02 (0.75–1.39)

0.91

0.87 (0.57–1.32)

0.51

 TC or CC

543

475

0.87 (0.69–1.09)

0.23

0.90 (0.71–1.13)

0.36

0.84 (0.62–1.14)

0.26

TLR9

rs187084

 TT

262

237

      

 TC

366

335

1.01 (0.80–1.27)

0.92

1.03 (0.82–1.31)

0.78

1.09 (0.79–1.50)

0.60

 CC

142

120

0.93 (0.69–1.26)

0.66

0.91 (0.67–1.24)

0.56

1.07 (0.71–1.61)

0.76

 TC or CC

508

455

0.99 (0.80–1.23)

0.93

1.00 (0.80–1.25)

0.98

1.08 (0.80–1.46)

0.60

TLR9

rs352139

 GG

255

211

      

 GA

347

324

1.13 (0.89–1.43)

0.32

1.08 (0.85–1.38)

0.52

1.01 (0.73–1.40)

0.93

 AA

167

139

1.01 (0.75–1.34)

0.97

0.96 (0.71–1.30)

0.79

0.80 (0.53–1.20)

0.27

 GA or AA

514

463

1.09 (0.87–1.36)

0.45

1.04 (0.83–1.31)

0.72

0.94 (0.69–1.27)

0.68

LY96

rs11465996

 CC

344

341

      

 CG

337

298

0.89 (0.72–1.11)

0.30

0.91 (0.73–1.14)

0.42

0.89 (0.66–1.20)

0.45

 GG

81

53

0.66 (0.45–0.96)

0.03

0.68 (0.46–1.00)

0.0498

0.65 (0.39–1.10)

0.11

 CG or GG

418

351

0.85 (0.69–1.04)

0.11

0.87 (0.70–1.07)

0.18

0.84 (0.63–1.12)

0.24

CD14

Rs2569190

 GG

236

194

      

 GA

360

339

1.15 (0.90–1.46)

0.27

1.18 (0.92–1.51)

0.19

1.27 (0.91–1.78)

0.16

 AA

170

157

1.12 (0.84–1.50)

0.43

1.20 (0.89–1.61)

0.24

1.46 (0.98–2.19)

0.06

 GA or AA

530

496

1.14 (0.91–1.43)

0.26

1.18 (0.94–1.50)

0.15

1.32 (0.96–1.82)

0.08

TIRAP

rs8177374

 CC

556

521

      

 CT

185

159

0.92 (0.72–1.17)

0.49

0.99 (0.77–1.27)

0.94

1.38 (0.99–1.91)

0.06

 TT

21

15

0.76 (0.39–1.49)

0.43

0.76 (0.38–1.53)

0.45

1.31 (0.55–3.12)

0.55

 CT or TT

206

174

0.90 (0.71–1.14)

0.39

0.97 (0.76–1.23)

0.81

1.38 (1.00–1.89)

0.047

SUMO4

rs237025

 TT

215

195

      

 TC

362

358

1.09 (0.86–1.39)

0.48

1.08 (0.84–1.38)

0.55

1.04 (0.75–1.44)

0.80

 CC

195

136

0.77 (0.57–1.03)

0.08

0.75 (0.55–1.01)

0.06

0.55 (0.36–0.84)

0.01

 TC or CC

557

494

0.98 (0.78–1.23)

0.85

0.96 (0.76–1.22)

0.75

0.87 (0.64–1.19)

0.38

NFKBIA

rs696

 GG

298

259

      

 GA

366

336

1.06 (0.85–1.32)

0.63

1.06 (0.84–1.33)

0.64

1.02 (0.75–1.39)

0.88

 AA

101

90

1.03 (0.74–1.43)

0.88

0.97 (0.69–1.36)

0.86

1.07 (0.67–1.69)

0.78

 GA or AA

467

426

1.05 (0.85–1.30)

0.65

1.04 (0.84–1.29)

0.73

1.03 (0.77–1.38)

0.84

NFKB1

rs28362491

 Ins/Ins

269

258

      

 Ins/−

376

316

0.88 (0.70–1.10)

0.25

0.89 (0.70–1.12)

0.31

0.74 (0.54–1.01)

0.06

 −/−

122

100

0.85 (0.62–1.17)

0.33

0.82 (0.59–1.13)

0.22

0.78 (0.51–1.19)

0.25

 Ins/− or −/−

498

416

0.87 (0.70–1.08)

0.21

0.87 (0.70–1.08)

0.21

0.75 (0.56–1.01)

0.06

TNF

rs1800629

 GG

527

549

      

 GA

223

129

0.56 (0.43–0.71)

0.0000032

0.58 (0.45–0.75)

0.000029

0.63 (0.45–0.89)

0.01

 AA

25

9

0.35 (0.16–0.75)

0.01

0.39 (0.18–0.85)

0.02

0.19 (0.04–0.79)

0.02

 GA or AA

248

138

0.53 (0.42–0.68)

0.00000030

0.56 (0.44–0.72)

0.0000047

0.59 (0.42–0.82)

0.0018

TNF

rs361525

 GG

708

669

      

 GA

60

30

0.53 (0.34–0.83)

0.01

0.52 (0.32–0.82)

0.0049

0.61 (0.33–1.12)

0.11

 AA

3

0

1.00 (1.00–1.00)

1.00

1.00 (1.00–1.00)

1.00

1.00 (1.00–1.00)

1.00

 GA or AA

63

30

0.50 (0.32–0.79)

0.0027

0.49 (0.31–0.78)

0.0024

0.58 (0.32–1.05)

0.07

TNFRSF1A

rs4149570

 GG

307

217

      

 GT

355

339

1.35 (1.07–1.70)

0.01

1.33 (1.05–1.68)

0.02

1.46 (1.06–2.00)

0.02

 TT

109

132

1.71 (1.26–2.33)

0.00060

1.79 (1.31–2.46)

0.00027

2.26 (1.48–3.47)

0.00017

 GT or TT

464

471

1.44 (1.16–1.78)

0.0010

1.44 (1.15–1.80)

0.0013

1.64 (1.21–2.22)

0.0014

TNFAIP3

rs6927172

 CC

473

415

      

 CG

264

245

1.06 (0.85–1.32)

0.61

1.06 (0.85–1.33)

0.61

1.03 (0.76–1.39)

0.85

 GG

40

25

0.71 (0.42–1.19)

0.20

0.70 (0.41–1.19)

0.18

0.51 (0.23–1.10)

0.09

 CG or GG

304

270

1.01 (0.82–1.25)

0.91

1.01 (0.82–1.26)

0.91

0.95 (0.71–1.27)

0.73

TGFB1

rs1800469

 CC

383

344

      

 CT

297

299

1.12 (0.90–1.39)

0.30

1.08 (0.87–1.35)

0.48

1.28 (0.95–1.71)

0.11

 TT

86

53

0.69 (0.47–1.00)

0.047

0.69 (0.47–1.02)

0.06

0.69 (0.40–1.17)

0.17

 CT or TT

383

352

1.02 (0.83–1.26)

0.83

1.00 (0.81–1.23)

0.97

1.14 (0.86–1.52)

0.35

PTPN22

rs2476601

 GG

588

557

      

 GA

166

122

0.78 (0.60–1.01)

0.06

0.77 (0.59–1.00)

0.05

0.75 (0.52–1.09)

0.13

 AA

11

6

0.58 (0.21–1.57)

0.28

0.57 (0.20–1.58)

0.28

0.83 (0.21–3.28)

0.80

 GA or AA

177

128

0.76 (0.59–0.99)

0.04

0.76 (0.58–0.98)

0.04

0.76 (0.53–1.09)

0.13

PPARG

rs1801282

 CC

548

511

      

 CG

207

167

0.87 (0.68–1.10)

0.23

0.85 (0.66–1.08)

0.18

0.87 (0.63–1.21)

0.42

 GG

14

15

1.15 (0.55–2.40)

0.71

1.33 (0.62–2.83)

0.46

1.54 (0.60–3.98)

0.37

 CG or GG

221

182

0.88 (0.70–1.11)

0.29

0.88 (0.69–1.11)

0.27

0.91 (0.67–1.26)

0.58

IL1B

rs4848306

 GG

246

215

      

 GA

373

352

1.08 (0.85–1.36)

0.52

1.09 (0.86–1.39)

0.48

1.16 (0.84–1.60)

0.38

 AA

151

125

0.95 (0.70–1.28)

0.72

0.96 (0.71–1.31)

0.81

0.88 (0.57–1.34)

0.55

 GA or AA

524

477

1.04 (0.83–1.30)

0.72

1.06 (0.84–1.33)

0.64

1.08 (0.79–1.46)

0.64

IL1B

rs1143623

 GG

401

365

      

 GC

316

278

0.97 (0.78–1.20)

0.76

0.98 (0.79–1.22)

0.87

1.07 (0.80–1.44)

0.66

 CC

55

52

1.04 (0.69–1.56)

0.85

1.12 (0.74–1.69)

0.59

0.87 (0.48–1.57)

0.64

 GC or CC

371

330

0.98 (0.80–1.20)

0.83

1.00 (0.81–1.24)

0.98

1.04 (0.78–1.38)

0.79

IL1B

rs1143627

 TT

340

305

      

 TC

339

305

1.00 (0.81–1.25)

0.98

1.00 (0.79–1.25)

0.97

1.05 (0.78–1.42)

0.75

 CC

97

86

0.99 (0.71–1.37)

0.94

1.01 (0.72–1.41)

0.95

0.85 (0.53–1.36)

0.50

 TC or CC

436

391

1.00 (0.81–1.23)

1.00

1.00 (0.81–1.24)

1.00

1.00 (0.76–1.34)

0.97

IL1RN

rs4251961

 TT

298

247

      

 TC

360

324

1.09 (0.87–1.36)

0.47

1.04 (0.83–1.32)

0.71

1.22 (0.89–1.67)

0.21

 CC

112

105

1.13 (0.83–1.55)

0.44

1.05 (0.76–1.46)

0.76

1.41 (0.92–2.17)

0.12

 TC or CC

472

429

1.10 (0.89–1.36)

0.40

1.05 (0.84–1.30)

0.68

1.26 (0.94–1.71)

0.12

IL4R

rs1805010

 AA

209

201

      

 AG

410

317

0.80 (0.63–1.02)

0.08

0.79 (0.62–1.02)

0.07

0.73 (0.52–1.02)

0.07

 GG

157

133

0.88 (0.65–1.19)

0.41

0.91 (0.67–1.24)

0.55

0.87 (0.58–1.33)

0.53

 AG or GG

567

450

0.83 (0.66–1.04)

0.10

0.83 (0.65–1.05)

0.12

0.77 (0.56–1.06)

0.11

IL6

rs10499563

 TT

476

439

      

 TC

259

225

0.94 (0.76–1.17)

0.60

0.94 (0.75–1.18)

0.60

0.77 (0.57–1.05)

0.10

 CC

35

26

0.81 (0.48–1.36)

0.42

0.72 (0.42–1.25)

0.24

0.80 (0.39–1.63)

0.53

 TC or CC

294

251

0.93 (0.75–1.14)

0.48

0.92 (0.74–1.14)

0.43

0.77 (0.57–1.04)

0.09

IL6R

rs4537545

 CC

289

247

      

 CT

369

324

1.03 (0.82–1.29)

0.82

1.05 (0.83–1.32)

0.71

1.07 (0.79–1.47)

0.65

 TT

117

113

1.13 (0.83–1.54)

0.44

1.18 (0.86–1.63)

0.30

1.17 (0.76–1.79)

0.48

 CT or TT

486

437

1.05 (0.85–1.30)

0.64

1.08 (0.86–1.34)

0.51

1.09 (0.81–1.47)

0.55

IL10

rs1800872

 CC

482

408

      

 CA

258

225

1.03 (0.83–1.29)

0.79

1.01 (0.80–1.27)

0.94

0.93 (0.68–1.26)

0.63

 AA

35

42

1.42 (0.89–2.26)

0.14

1.35 (0.83–2.18)

0.22

1.47 (0.79–2.73)

0.22

 CA or AA

293

267

1.08 (0.87–1.33)

0.50

1.05 (0.84–1.30)

0.67

0.99 (0.74–1.33)

0.95

IL10

rs3024505

 CC

518

467

      

 CT

221

200

1.00 (0.80–1.26)

0.97

1.01 (0.80–1.28)

0.95

1.19 (0.87–1.61)

0.28

 TT

22

24

1.21 (0.67–2.19)

0.53

1.32 (0.72–2.42)

0.37

1.80 (0.79–4.12)

0.16

 CT or TT

243

224

1.02 (0.82–1.27)

0.84

1.04 (0.83–1.30)

0.76

1.23 (0.92–1.66)

0.17

IL12B

rs3212217

 GG

499

460

      

 GC

235

200

0.92 (0.74–1.16)

0.49

0.95 (0.75–1.19)

0.64

0.94 (0.69–1.29)

0.72

 CC

25

21

0.91 (0.50–1.65)

0.76

0.94 (0.51–1.72)

0.84

0.57 (0.23–1.41)

0.22

 GC or CC

260

221

0.92 (0.74–1.15)

0.47

0.95 (0.76–1.19)

0.63

0.91 (0.67–1.23)

0.53

IL12B

rs6887695

 GG

385

324

      

 GC

293

301

1.22 (0.98–1.52)

0.07

1.24 (0.99–1.55)

0.06

1.31 (0.97–1.77)

0.07

 CC

72

70

1.16 (0.81–1.66)

0.43

1.16 (0.80–1.69)

0.43

0.98 (0.59–1.61)

0.94

 GC or CC

365

371

1.21 (0.98–1.49)

0.07

1.22 (0.99–1.51)

0.06

1.24 (0.93–1.64)

0.14

IL12RB1

rs401502

 CC

360

304

      

 CG

303

311

1.22 (0.98–1.51)

0.08

1.21 (0.96–1.51)

0.10

1.19 (0.88–1.61)

0.26

 GG

87

70

0.95 (0.67–1.35)

0.79

0.97 (0.68–1.39)

0.87

1.18 (0.74–1.88)

0.48

 CG or GG

390

381

1.16 (0.94–1.42)

0.17

1.15 (0.93–1.43)

0.19

1.19 (0.89–1.58)

0.24

IL17A

rs2275913

 GG

340

307

      

 GA

336

301

0.99 (0.80–1.24)

0.94

0.98 (0.79–1.23)

0.89

0.90 (0.67–1.22)

0.51

 AA

95

84

0.98 (0.70–1.36)

0.90

1.00 (0.71–1.40)

0.98

1.00 (0.63–1.57)

0.99

 GA or AA

431

385

0.99 (0.80–1.22)

0.92

0.99 (0.80–1.22)

0.89

0.92 (0.69–1.22)

0.57

IL18

rs187238

 GG

387

380

      

 GC

312

259

0.85 (0.68–1.05)

0.13

0.83 (0.66–1.03)

0.09

0.74 (0.55–1.00)

0.049

 CC

64

41

0.65 (0.43–0.99)

0.04

0.69 (0.45–1.06)

0.09

0.58 (0.32–1.04)

0.07

 GC or CC

376

300

0.81 (0.66–1.00)

0.0499

0.80 (0.65–0.99)

0.04

0.71 (0.53–0.95)

0.02

IL18

rs1946518

 GG

282

259

      

 GT

363

329

0.99 (0.79–1.24)

0.91

0.96 (0.76–1.21)

0.71

0.89 (0.65–1.21)

0.45

 TT

113

97

0.93 (0.68–1.29)

0.68

0.95 (0.68–1.31)

0.74

0.80 (0.51–1.24)

0.32

 GT or TT

476

426

0.97 (0.79–1.21)

0.81

0.96 (0.77–1.19)

0.68

0.86 (0.64–1.16)

0.32

IL23R

rs11209026

 GG

680

646

      

 GA

89

50

0.59 (0.41–0.85)

0.0045

0.63 (0.43–0.91)

0.02

0.64 (0.38–1.05)

0.08

 AA

5

1

1.00 (1.00–1.00)

1.00

1.00 (1.00–1.00)

1.00

1.00 (1.00–1.00)

1.00

 GA or AA

94

51

0.57 (0.40–0.82)

0.0021

0.60 (0.42–0.87)

0.01

0.63 (0.38–1.03)

0.06

IFNG

rs2430561

 TT

199

181

      

 TA

398

369

1.02 (0.80–1.30)

0.88

1.01 (0.79–1.30)

0.92

1.08 (0.77–1.52)

0.65

 AA

161

139

0.95 (0.70–1.29)

0.74

0.97 (0.71–1.32)

0.85

1.09 (0.72–1.64)

0.68

 TA or AA

559

508

1.00 (0.79–1.26)

0.99

1.00 (0.79–1.27)

0.99

1.08 (0.79–1.50)

0.62

IFNGR1

rs2234711

 TT

290

232

      

 TC

361

348

1.20 (0.96–1.51)

0.11

1.20 (0.95–1.51)

0.12

1.15 (0.84–1.57)

0.40

 CC

119

108

1.13 (0.83–1.55)

0.43

1.09 (0.79–1.50)

0.60

1.11 (0.72–1.70)

0.65

 TC or CC

480

456

1.19 (0.96–1.47)

0.12

1.17 (0.94–1.46)

0.16

1.14 (0.84–1.53)

0.40

IFNGR2

rs8126756

 TT

553

522

      

 TC

168

130

0.82 (0.63–1.06)

0.13

0.83 (0.64–1.09)

0.18

0.86 (0.60–1.24)

0.42

 CC

18

12

0.71 (0.34–1.48)

0.36

0.69 (0.32–1.49)

0.35

0.53 (0.18–1.54)

0.24

 TC or CC

186

142

0.81 (0.63–1.04)

0.09

0.82 (0.64–1.06)

0.13

0.83 (0.59–1.17)

0.28

IFNGR2

rs17882748

 CC

199

173

      

 CT

391

341

1.00 (0.78–1.29)

0.98

1.00 (0.77–1.30)

0.99

1.01 (0.71–1.42)

0.97

 TT

153

174

1.31 (0.97–1.76)

0.08

1.31 (0.97–1.78)

0.08

1.16 (0.77–1.73)

0.48

 CT or TT

544

515

1.09 (0.86–1.38)

0.48

1.09 (0.86–1.39)

0.48

1.05 (0.76–1.45)

0.76

TBX21

rs17250932

 TT

526

497

      

 TC

210

179

0.90 (0.71–1.14)

0.39

0.94 (0.74–1.19)

0.61

0.84 (0.60–1.17)

0.30

 CC

32

19

0.63 (0.35–1.12)

0.12

0.66 (0.36–1.19)

0.17

0.37 (0.14–0.98)

0.046

 TC or CC

242

198

0.87 (0.69–1.08)

0.21

0.90 (0.72–1.14)

0.39

0.78 (0.56–1.07)

0.12

NLRP1

rs2670660

 AA

222

202

      

 AG

390

328

0.92 (0.73–1.18)

0.52

0.96 (0.75–1.23)

0.73

1.12 (0.80–1.56)

0.52

 GG

154

154

1.10 (0.82–1.47)

0.53

1.11 (0.82–1.49)

0.51

1.12 (0.75–1.67)

0.59

 AG or GG

544

482

0.97 (0.78–1.22)

0.82

1.00 (0.79–1.26)

0.98

1.11 (0.81–1.52)

0.50

NLRP1

rs878329

 GG

217

206

      

 GC

394

333

0.89 (0.70–1.13)

0.34

0.89 (0.69–1.14)

0.35

0.99 (0.71–1.38)

0.93

 CC

155

155

1.05 (0.79–1.41)

0.73

1.05 (0.78–1.41)

0.75

1.03 (0.69–1.54)

0.90

 GC or CC

549

488

0.94 (0.75–1.17)

0.57

0.93 (0.74–1.18)

0.56

1.00 (0.73–1.36)

0.98

NLRP3

rs10754558

 CC

294

248

      

 CG

355

324

1.08 (0.86–1.36)

0.50

1.06 (0.84–1.34)

0.61

1.10 (0.81–1.51)

0.54

 GG

111

116

1.24 (0.91–1.69)

0.18

1.25 (0.91–1.71)

0.17

1.11 (0.71–1.72)

0.65

 CG or GG

466

440

1.12 (0.90–1.39)

0.30

1.11 (0.89–1.38)

0.36

1.11 (0.82–1.49)

0.51

NLRP3

rs4612666

 CC

435

360

      

 CT

280

277

1.20 (0.96–1.49)

0.11

1.23 (0.99–1.54)

0.07

1.28 (0.95–1.72)

0.10

 TT

53

48

1.09 (0.72–1.66)

0.67

1.19 (0.78–1.82)

0.41

1.07 (0.59–1.94)

0.82

 CT or TT

333

325

1.18 (0.96–1.45)

0.12

1.23 (0.99–1.52)

0.06

1.24 (0.94–1.65)

0.13

CARD8

rs2043211

 AA

321

298

      

 AT

342

316

1.00 (0.80–1.24)

0.97

0.98 (0.79–1.23)

0.89

0.90 (0.67–1.22)

0.50

 TT

94

78

0.89 (0.64–1.25)

0.52

0.89 (0.63–1.26)

0.50

0.91 (0.57–1.44)

0.68

 AT or TT

436

394

0.97 (0.79–1.20)

0.80

0.96 (0.78–1.19)

0.72

0.90 (0.67–1.19)

0.45

JAK2

rs12343867

 TT

398

358

      

 TC

299

263

0.98 (0.79–1.22)

0.84

0.96 (0.76–1.20)

0.69

0.82 (0.61–1.12)

0.21

 CC

61

65

1.18 (0.81–1.73)

0.38

1.11 (0.75–1.63)

0.61

1.03 (0.62–1.71)

0.91

 TC or CC

360

328

1.01 (0.82–1.25)

0.90

0.98 (0.79–1.21)

0.86

0.86 (0.64–1.14)

0.29