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Table 5 Frequencies of inferred haplotypes among the cases and controls and their association with risk of NIHL

From: Notch polymorphisms associated with sensitivity of noise induced hearing loss among Chinese textile factory workers

Haplotypes a

Case (n = 535*2)

Control (n = 535*2)

P b

Adjusted OR

Global P c

n

%

n

%

(95% CI)

GAC

787

73.6

398

37.2

 

1.00 (Ref.)

< 0.001

GGC

89

8.3

413

38.6

< 0.001

0.11 (0.08–0.14)

 

GGT

7

0.7

221

20.7

< 0.001

0.02 (0.01–0.03)

 

AAC

118

11.0

4

0.4

< 0.001

14.95 (5.48–40.79)

 

Others d

69

6.4

34

3.2

0.972

1.01(0.66–1.55)

 
  1. aThe alleles of haplotypes were arrayed as rs3124594-rs3124599-rs3124603
  2. bTwo-sided χ2 test
  3. cGenerated by permutation test with 1000 times of simulation
  4. dHaplotypes with a frequency < 0.03 (AAC/AAT/AGT/GAT) were pooled into the mixed group
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BMC Medical Genetics

ISSN: 1471-2350

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