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Table 1 Hematological features, Hb electrophoresis and the genotype analysis of the proband’s family

From: The phenomena of balanced effect between α-globin gene and of β-globin gene

parameters

I:1

I:2

II:1

II:2

II:3

III:1

Reference

Sex/Age (years)

M/55

F/52

F/34

M/32

F/30

M/1

RBC (× 1012/L)

5.8

5.2

4.8

6.2

5.6

3.63

4.0–5.5

Hb (g/L)

141

122

125

133

118

57

120–160

MCV (fL)

82.6

65.1

80.5

63.6

64.8

48.8

82–95

MCH (pg)

28.5

21.1

30.1

21

21

15.7

27–31

MCHC (g/L)

340

338

335

333

330

322

320-3 s60

HbA2 (%)

2.9

5.2

3

5.7

5.2

3.2

2.5–3.5

HbA0 (%)

89

85.3

90.1

81.2

84.4

61.7

≥80

HbF (%)

0.8

1.2

1

1.5

0.4

35.1

0.0–2.3

RDW (%)

14

16

13

17

24

30

12–15

α genotype

3.7/αα

αα/αα

αα/αα

3.7/αα

--SEA /αα

--SEA/−α3.7

β genotype

βNN

βNCD41–42

βNN

βNCD41–42

βNIVS-II-654

βCD41–42IVS-II-654

  1. RBC red blood cell, Hb hemoglobin, MCV mean cell volume, MCH mean cell hemoglobin, MCHC mean cell hemoglobin concentration, M male, F female, βN normal β-globin gene, I:1 grandfather, I:2 grandmother, II:1 father’s sister, II:2 father, II:3 mother, III:1 proband