Table 4 Prediction Models for Post-bronchodilator Lung Function
From: Genome-wide association study of lung function and clinical implication in heavy smokers
Post-bronchodilator FEV1/FVC | Post-bronchodilator % predicted FEV1 | |||||
|---|---|---|---|---|---|---|
β | R2 | P value | β | R2 | P value | |
Genetic Score (8–18)a | − 0.018 | 0.0363 | 8.6 × 10− 15 | −2.6 | 0.0296 | 2.7 × 10− 12 |
Age at enrollment, years | −0.0024 | 0.0145 | 1.1 × 10− 6 | − 0.042 | 0.000176 | 0.59 |
Sex (Male = 0, Female = 1) | 0.044 | 0.0186 | 3.1 × 10− 8 | 1.88 | 0.000132 | 0.14 |
Pack-years of cigarette smoking | − 0.0011 | 0.0304 | 1.3 × 10− 12 | −0.017 | 0.0294 | 3.2 × 10− 12 |
All | NA | 0.0859 | < 2.2 × 10− 16 | NA | 0.0583 | < 2.2 × 10− 16 |