Skip to main content

Table 4 Prediction Models for Post-bronchodilator Lung Function

From: Genome-wide association study of lung function and clinical implication in heavy smokers

  Post-bronchodilator FEV1/FVC Post-bronchodilator % predicted FEV1
β R2 P value β R2 P value
Genetic Score (8–18)a − 0.018 0.0363 8.6 × 10− 15 −2.6 0.0296 2.7 × 10− 12
Age at enrollment, years −0.0024 0.0145 1.1 × 10− 6 − 0.042 0.000176 0.59
Sex (Male = 0, Female = 1) 0.044 0.0186 3.1 × 10− 8 1.88 0.000132 0.14
Pack-years of cigarette smoking − 0.0011 0.0304 1.3 × 10− 12 −0.017 0.0294 3.2 × 10− 12
All NA 0.0859 <  2.2 × 10− 16 NA 0.0583 <  2.2 × 10− 16
  1. aGenetic scores (the number of risk alleles) of 10 candidate SNPs (rs28929474 in SERPINA1, rs1980057 in HHIP, rs2869967 in FAM13A1, rs2070600 in AGER, rs1435867 in PID1, rs12477314 in HDAC4, rs1529672 in RARB, rs12914385 in CHRNA3, rs10498635 in RIN3, and rs615098 in MMP12). 1632 SPIROMICS non-Hispanic White smokers (GOLD stage 0–4) were included. Eight subjects with TT genotype of rs28929474 in SERPINA1 (PiZZ genotype) were excluded