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Table 2 Association Results of the Top SNPs (P < 10− 6) and Candidate Lung Function and COPD SNPs (P < 0.05)

From: Genome-wide association study of lung function and clinical implication in heavy smokers

SNP Gene Chr Location Minor (Effect)/Major Allele Minor AlleleFrequency Post-bronchodilator
FEV1/FVC
Post-bronchodilator
% predicted FEV1
β P value β P value
rs28929474 SERPINA1 14 coding T/C 0.029 −0.087 1.2 × 10−8 −13.6 3.5 × 10− 8
rs4537555 HHAT 1 intron G/A 0.11 − 0.044 2.1 × 10− 7 − 6.3 4.1 × 10− 6
rs8079868 MYH3 17 3’ C/T 0.12 − 0.034 3.5 × 10− 5 −6.7 5.9 × 10− 7
rs1980057 HHIP 4 5’ T/C 0.37 0.011 0.049 1.4 0.13
rs2070600 AGER 6 coding A/G 0.047 0.026 0.047 3.4 0.10
rs2869967 FAM13A1 4 intron C/T 0.41 −0.014 0.016 −1.4 0.12
rs1435867 PID1 2 3’ C/T 0.075 0.021 0.043 1.9 0.26
rs12477314 HDAC4 2 3’ T/C 0.21 0.014 0.033 2.3 0.035
rs1529672 RARB 3 intron A/C 0.15 0.026 5.1 × 10−4 3.4 5.0 × 10− 3
rs12914385 CHRNA3 15 intron T/C 0.43 −0.014 0.014 −2.2 0.014
rs10498635 RIN3 14 intron T/C 0.18 0.021 2.6 × 10−3 3.7 1.5 × 10− 3
rs615098 MMP12 11 3’ A/C 0.18 0.013 0.056 2.4 0.034
  1. Association analyses of Post-bronchodilator % predicted FEV1 and FEV1/FVC were performed using linear regression adjusted for age, sex, current smoking status, pack-years of cigarette smoking, and the first two principal components