From: Genome-wide association study of lung function and clinical implication in heavy smokers
SNP | Gene | Chr | Location | Minor (Effect)/Major Allele | Minor AlleleFrequency | Post-bronchodilator FEV1/FVC | Post-bronchodilator % predicted FEV1 | ||
---|---|---|---|---|---|---|---|---|---|
β | P value | β | P value | ||||||
rs28929474 | SERPINA1 | 14 | coding | T/C | 0.029 | −0.087 | 1.2 × 10−8 | −13.6 | 3.5 × 10− 8 |
rs4537555 | HHAT | 1 | intron | G/A | 0.11 | − 0.044 | 2.1 × 10− 7 | − 6.3 | 4.1 × 10− 6 |
rs8079868 | MYH3 | 17 | 3’ | C/T | 0.12 | − 0.034 | 3.5 × 10− 5 | −6.7 | 5.9 × 10− 7 |
rs1980057 | HHIP | 4 | 5’ | T/C | 0.37 | 0.011 | 0.049 | 1.4 | 0.13 |
rs2070600 | AGER | 6 | coding | A/G | 0.047 | 0.026 | 0.047 | 3.4 | 0.10 |
rs2869967 | FAM13A1 | 4 | intron | C/T | 0.41 | −0.014 | 0.016 | −1.4 | 0.12 |
rs1435867 | PID1 | 2 | 3’ | C/T | 0.075 | 0.021 | 0.043 | 1.9 | 0.26 |
rs12477314 | HDAC4 | 2 | 3’ | T/C | 0.21 | 0.014 | 0.033 | 2.3 | 0.035 |
rs1529672 | RARB | 3 | intron | A/C | 0.15 | 0.026 | 5.1 × 10−4 | 3.4 | 5.0 × 10− 3 |
rs12914385 | CHRNA3 | 15 | intron | T/C | 0.43 | −0.014 | 0.014 | −2.2 | 0.014 |
rs10498635 | RIN3 | 14 | intron | T/C | 0.18 | 0.021 | 2.6 × 10−3 | 3.7 | 1.5 × 10− 3 |
rs615098 | MMP12 | 11 | 3’ | A/C | 0.18 | 0.013 | 0.056 | 2.4 | 0.034 |