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Table 2 Association Results of the Top SNPs (P < 10− 6) and Candidate Lung Function and COPD SNPs (P < 0.05)

From: Genome-wide association study of lung function and clinical implication in heavy smokers

SNP

Gene

Chr

Location

Minor (Effect)/Major Allele

Minor AlleleFrequency

Post-bronchodilator

FEV1/FVC

Post-bronchodilator

% predicted FEV1

β

P value

β

P value

rs28929474

SERPINA1

14

coding

T/C

0.029

−0.087

1.2 × 10−8

−13.6

3.5 × 10− 8

rs4537555

HHAT

1

intron

G/A

0.11

− 0.044

2.1 × 10− 7

− 6.3

4.1 × 10− 6

rs8079868

MYH3

17

3’

C/T

0.12

− 0.034

3.5 × 10− 5

−6.7

5.9 × 10− 7

rs1980057

HHIP

4

5’

T/C

0.37

0.011

0.049

1.4

0.13

rs2070600

AGER

6

coding

A/G

0.047

0.026

0.047

3.4

0.10

rs2869967

FAM13A1

4

intron

C/T

0.41

−0.014

0.016

−1.4

0.12

rs1435867

PID1

2

3’

C/T

0.075

0.021

0.043

1.9

0.26

rs12477314

HDAC4

2

3’

T/C

0.21

0.014

0.033

2.3

0.035

rs1529672

RARB

3

intron

A/C

0.15

0.026

5.1 × 10−4

3.4

5.0 × 10− 3

rs12914385

CHRNA3

15

intron

T/C

0.43

−0.014

0.014

−2.2

0.014

rs10498635

RIN3

14

intron

T/C

0.18

0.021

2.6 × 10−3

3.7

1.5 × 10− 3

rs615098

MMP12

11

3’

A/C

0.18

0.013

0.056

2.4

0.034

  1. Association analyses of Post-bronchodilator % predicted FEV1 and FEV1/FVC were performed using linear regression adjusted for age, sex, current smoking status, pack-years of cigarette smoking, and the first two principal components