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Table 4 Additive and multiplicative interaction analyses between COMT Val158Met and depression for later cardiovascular disease (CVD) (n = 3525)

From: Association of Catechol-O-methyltransferase (COMT Val158Met) with future risk of cardiovascular disease in depressed individuals - a Swedish population-based cohort study

Interaction indices Estimate (95% CI)
Additive interactiona
 RERI 2.06 (− 0.22-4.3)
 AP 0.56 (0.24-0.88)
 S 4.39 (1.0-18.7)
Multiplicative interaction Odds ratio (95% CI)
Model 1 - main effects
  Depression (yes) 1.4 (1.0-2.0)
  Val/Val 1.3 (1.0-1.8)
Model 2 – main and interaction effects
  Depression (yes) 1.2 (0.70-1.7)
  Val/Val 1.1 (0.80-1.6)
  Depression x Val158Met 2.2 (1.0-4.7)
  P-value (Model 2 versus Model 1) 0.10b
  1. aRERI: the relative excess risk due to interaction
  2. AP the attributable proportion due to interaction
  3. S the synergy index
  4. AP > 0 and S > 1 indicate additive interaction
  5. bLog likelihood test (− 2 log likelihood: Model 1 = 1725.6; Model 2 = 1721.2)