Table 4 Additive and multiplicative interaction analyses between COMT Val¹⁵⁸Met and depression for later cardiovascular disease (CVD) (n = 3525)

 RERI

2.06 (− 0.22-4.3)

 AP

0.56 (0.24-0.88)

 S

4.39 (1.0-18.7)

Multiplicative interaction

Odds ratio (95% CI)

  Depression (yes)

1.4 (1.0-2.0)

  Val/Val

1.3 (1.0-1.8)

  Depression (yes)

1.2 (0.70-1.7)

  Val/Val

1.1 (0.80-1.6)

  Depression x Val¹⁵⁸Met

2.2 (1.0-4.7)

  P-value (Model 2 versus Model 1)

0.10^b