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Table 3 Interaction between COMT Val158Met and depression for later cardiovascular disease (CVD), stratified by gender

From: Association of Catechol-O-methyltransferase (COMT Val158Met) with future risk of cardiovascular disease in depressed individuals - a Swedish population-based cohort study

 

All (n = 3525)

Men (n = 1495)

Women (n = 2030)

Met/Met or Met/Val

Val/Val

Met/Met or Met/Val

Val/Val

Met/Met or Met/Val

Val/Val

n = 2814

n = 711

n = 1179

n = 316

n = 1635

n = 395

Depression

n CVD/n Non-CVD

 No

146 /2205

42/576

102/947

31/258

44/1258

11/318

 Yes

33/430

15/78

15/115

4/23

18/315

11/55

 

Odds ratio (95% confidence interval)a

Depression

 No

1 (Ref)

1.1 (0.8 1.6)

1 (Ref)

1.1 (0.73 1.7)

1 (Ref)

1.0 (0.50 2.0)

 P values

–

0.5

–

0.5

–

0.10

 Yes

1.5 (1.0-2.3)

3.6 (2.0-6.6)

1.8 (1.0-3.4)

2.1 (1.0 6.8)

2.0 (1.1 3.5)

7.0 (3.0 14.0)

 P values

0.03

< 0.001

0.05

0.20

0.01

< 0.001

  1. aOdds ratio (OR) for Val/Val (G/G) with no depression, Val/Val (G/G) with depression, and Met carriers (A/A plus A/G) with depression, adjusted for age and body mass index. Met carriers (A/A plus A/G) with no depression was the reference group