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Table 3 Interaction between COMT Val158Met and depression for later cardiovascular disease (CVD), stratified by gender

From: Association of Catechol-O-methyltransferase (COMT Val158Met) with future risk of cardiovascular disease in depressed individuals - a Swedish population-based cohort study

  All (n = 3525) Men (n = 1495) Women (n = 2030)
Met/Met or Met/Val Val/Val Met/Met or Met/Val Val/Val Met/Met or Met/Val Val/Val
n = 2814 n = 711 n = 1179 n = 316 n = 1635 n = 395
Depression n CVD/n Non-CVD
 No 146 /2205 42/576 102/947 31/258 44/1258 11/318
 Yes 33/430 15/78 15/115 4/23 18/315 11/55
  Odds ratio (95% confidence interval)a
Depression
 No 1 (Ref) 1.1 (0.8 1.6) 1 (Ref) 1.1 (0.73 1.7) 1 (Ref) 1.0 (0.50 2.0)
P values 0.5 0.5 0.10
 Yes 1.5 (1.0-2.3) 3.6 (2.0-6.6) 1.8 (1.0-3.4) 2.1 (1.0 6.8) 2.0 (1.1 3.5) 7.0 (3.0 14.0)
P values 0.03 < 0.001 0.05 0.20 0.01 < 0.001
  1. aOdds ratio (OR) for Val/Val (G/G) with no depression, Val/Val (G/G) with depression, and Met carriers (A/A plus A/G) with depression, adjusted for age and body mass index. Met carriers (A/A plus A/G) with no depression was the reference group