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Table 4 Details of protection from bias for genetic variants significantly associated with prostate and endometrial cancers risk in meta-analyses

From: Cumulative evidence for relationships between multiple variants of HNF1B and the risk of prostate and endometrial cancers

Variants Cancer site Cancer risk Venice criteria grade Protection from bias Reason for bias Reason for bias exemption Initial study influence Deviation from HWE OR < 1.15 p value for publication bias p value for small study bias
OR (95% CI) p value OR (95% CI) p value
rs4430796 prostate 1.247 (1.218–1.276) 2.21 × 10−77 AAA A NA Identified by GWAS 1.244 (1.215–1.273) 2.07 × 10−74 No No 0.253 0.248
rs7501939 prostate 1.201 (1.164–1.239) 9.31 × 10−31 AAA A NA Identified by GWAS 1.200 (1.162–1.238) 1.31 × 10−29 No No 0.864 0.868
rs11649743 prostate 1.138 (1.062–1.219) 1.08 × 10−12 AAA A Low OR Identified by GWAS 1.136(1.053–1.226) 0.001 No Yes 0.588 0.580
rs3760511 prostate 1.214 (1.113–1.325) 1.57 × 10−19 AAA A NA Identified by GWAS 1.228 (1.139–1.224) 1.04 × 10−7 No No 0.778 0.770
rs4430796 endometrium 1.217 (1.160–1.276) 8.98 × 10−16 AAA A NA Identified by GWAS 1.202 (1.105–1.308) 1.87 × 10−5 No No 0.950 0.943
  1. HWE = P value for Hardy-Weinberg equilibrium;
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BMC Medical Genetics

ISSN: 1471-2350

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