Table 4 Details of protection from bias for genetic variants significantly associated with prostate and endometrial cancers risk in meta-analyses
Variants | Cancer site | Cancer risk | Venice criteria grade | Protection from bias | Reason for bias | Reason for bias exemption | Initial study influence | Deviation from HWE | OR < 1.15 | p value for publication bias | p value for small study bias | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
OR (95% CI) | p value | OR (95% CI) | p value | ||||||||||
rs4430796 | prostate | 1.247 (1.218–1.276) | 2.21 × 10−77 | AAA | A | NA | Identified by GWAS | 1.244 (1.215–1.273) | 2.07 × 10−74 | No | No | 0.253 | 0.248 |
rs7501939 | prostate | 1.201 (1.164–1.239) | 9.31 × 10−31 | AAA | A | NA | Identified by GWAS | 1.200 (1.162–1.238) | 1.31 × 10−29 | No | No | 0.864 | 0.868 |
rs11649743 | prostate | 1.138 (1.062–1.219) | 1.08 × 10−12 | AAA | A | Low OR | Identified by GWAS | 1.136(1.053–1.226) | 0.001 | No | Yes | 0.588 | 0.580 |
rs3760511 | prostate | 1.214 (1.113–1.325) | 1.57 × 10−19 | AAA | A | NA | Identified by GWAS | 1.228 (1.139–1.224) | 1.04 × 10−7 | No | No | 0.778 | 0.770 |
rs4430796 | endometrium | 1.217 (1.160–1.276) | 8.98 × 10−16 | AAA | A | NA | Identified by GWAS | 1.202 (1.105–1.308) | 1.87 × 10−5 | No | No | 0.950 | 0.943 |