Association between DSCAM polymorphisms and non-syndromic Hirschsprung disease in Chinese population

BMC Medical Genetics

Table 3 The association results of two SNPs in DSCAM to different subclinical features classified by aganglionois length including short-length (S-HSCR), long-length (L-HSCR) and TCA

Length of Aganglionosis	CHR	SNP	BP	A1/A2	F_A	F_U	P	OR	CI 0.95
SHSCR	21	rs2837770	40,662,426	G/A	0.59	0.54	3.06E-03	1.21	(1.07~ 1.38)
SHSCR	21	rs8134673	40,676,385	G/A	0.59	0.54	3.33E-03	1.21	(1.07~ 1.38)
LHSCR	21	rs2837770	40,662,426	G/A	0.56	0.54	0.63	1.05	(0.86~ 1.27)
LHSCR	21	rs8134673	40,676,385	G/A	0.54	0.54	0.91	1.01	(0.84~ 1.22)
TCA	21	rs2837770	40,662,426	G/A	0.56	0.54	0.66	1.07	(0.78~ 1.48)
TCA	21	rs8134673	40,676,385	G/A	0.57	0.54	0.2	1.12	(0.81~ 1.55)

CHR Chromosome, SNP Single Nucleotide Polymorphism, BP Base pair of where the SNP is located. A1/A2 indicates the risk allele and protective allele to disease; F_A/F_U indicates risk allele frequency of the SNP in cases or controls. The P value indicates the significance based on allelic association tests. The calculation of odds ratio (OR) is also based on the risk allele of each SNP

ISSN: 1471-2350