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Table 2 Summary of odds ratios (95% CI) in the analysis of the relationship between VEGF gene polymorphisms in rs699947 and coronary artery disease susceptibility

From: Association of genetic polymorphisms in vascular endothelial growth factor with susceptibility to coronary artery disease: a meta–analysis

Genetic Model Overall and Subgroups N Test of Association Test of Heterogeneity
  OR 95%CI P –value P Heterogeneity I2 (%)
  Overall 8 1.17 0.93,1.47 0.170 0.040 52%
  HWE (yes) 7 1.10 0.83,1.47 0.520 0.050 53%
  PB 3 1.38 1.19,1.61 0.000 0.950 0%
CC+ AC vs. AA HB 5 0.99 0.65,1.51 0.970 0.040 65%
  Large sample size 3 1.34 1.16,1.56 0.000 0.340 8%
  Small sample size 5 1.06 0.67,1.68 0.800 0.040 61%
  Asians 5 1.11 0.79,1.55 0.550 0.009 71%
  Caucasians 3 1.21 0.89,1.64 0.220 0.620 0%
  Overall 8 0.96 0.71,1.31 0.800 0.000 75%
  HWE (yes) 7 0.90 0.63,1.27 0.550 0.000 74%
  PB 3 0.98 0.53,1.80 0.950 0.003 83%
CC vs. AA+ AC HB 5 0.87 0.66,1.14 0.320 0.130 45
  Large sample 3 1.13 0.80,1.60 0.480 0.010 78%
  Small sample 5 0.80 0.47,1.37 0.420 0.006 73%
  Asians 5 0.99 0.74,1.48 0.790 0.000 79%
  Caucasians 3 0.65 0.27,1.56 0.340 0.010 78%
  Overall 8 1.26 1.10,1.45 0.001 0.210 27%
  HWE (yes) 7 1.20 1.00,1.44 0.050 0.180 32%
  PB 3 1.36 1.15,1.60 0.000 0.510 0%
AC vs. AA HB 5 1.05 0.81,1.37 0.710 0.210 32%
  Large sample 3 1.30 1.11,1.52 0.001 0.680 0%
  Small sample 5 1.16 0.88,1.54 0.290 0.080 53%
  Asians 5 1.25 1.07,1.46 0.005 0.150 41%
  Caucasians 3 1.33 0.97,1.83 0.080 0.250 29%
  Overall 8 1.05 0.71,1.55 0.810 0.001 72%
  HWE (yes) 7 0.95 0.59,1.53 0.770 0.001 72%
  PB 3 1.29 0.77,2.17 0.340 0.030 72%
CC vs. AA HB 5 0.95 0.57,1.60 0.850 0.020 65%
  Large sample 3 1.36 0.99,1.88 0.060 0.110 54%
  Small sample 5 0.82 0.39,1.71 0.600 0.004 74%
  Asians 5 1.12 0.68,1.83 0.660 0.001 79%
  Caucasians 3 0.88 0.41,1.89 0.740 0.070 62%
  Overall 8 1.01 0.83,1.23 0.930 0.000 80%
  HWE (yes) 7 0.96 0.77,1.21 0.750 0.000 77%
  PB 3 1.14 0.90,1.45 0.280 0.020 73%
C vs. A HB 5 0.95 0.73,1.22 0.680 0.008 71%
  Large sample 3 1.13 0.90,1.43 0.290 0.005 81%
  Small sample 5 0.92 0.67,1.27 0.620 0.005 73%
  Asians 5 1.04 0.79,1.37 0.790 0.000 86%
  Caucasians 3 0.97 0.75,1.26 0.820 0.180 42%
  1. Abbreviations: N number of studies; OR odds ratio; CI confidence interval; HB hospital–based; PB population–based; P–Value, P value for association; P Heterogeneity, P value for heterogeneity