The altered activity of P53 signaling pathway by STK11 gene mutations and its cancer phenotype in Peutz-Jeghers syndrome

Table 1 Characteristics of the cohort with PJS

Characteristics		Number (percentage)
Probands with mutation test		31
Mutation detected		17	54.8%
Probands enrolled in the luciferase analysis		13
Age^a Median (range)	D	25 (12–37) years
	F	28 (11–39) years
	P	33 (24–51) years
Gender
Male		7	51.8%
Female		6	48.2%
Family history
Familial		7	51.8%
Sporadic		6	48.2%
Cancer history		5	38.5%

^a D, diagnosis; F, first polypectomy or laparotomy; P, present. There were 12 probands having polypectomy

ISSN: 1471-2350