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Table 2 Top SNPs associated with blood pressure dipping (night-to-day blood pressure ratio) in GENRES and replication in DYNAMIC and DILGOM

From: Genome-wide association study of nocturnal blood pressure dipping in hypertensive patients

Discovery GWAS in GENRES Replication in DYNAMIC Replication in DILGOM
SNP Chr Gene EA/ OA SBP/ DBP EAF n β (%) P EAF n β (%) P Direction EAF n β (%) P Direction
rs4905794 14 BCL11B G/A SBP 0.08 204 −4.8 9.6 × 10−9 0.10 183 −0.8 0.4 same 0.11 180 0.9 0.3 opposite
eQTL DBP    −4.3 2.2 × 10−6    −1.6 0.13 same    1.0 0.4 opposite
rs2119704 14 GPR65 A/C SBP 0.07 204 −2.9 1.7 × 10−3 0.06 183 1.4 0.2 opposite 0.06 180 0.9 0.5 opposite
eQTL DBP    −4.6 3.4 × 10−6    1.1 0.4 opposite    −0.4 0.8 same
rs10817396 9 SNX30 G/A SBP 0.17 204 1.9 2.4 × 10−3 0.18 183 0.3 0.7 same 0.20 180 0.3 0.7 same
intron DBP    3.1 5.5 × 10−6    −0.1 0.9 opposite    0.6 0.6 same
rs16984571 2 KCNS3 G/A SBP 0.15 201 −2.7 5.6 × 10−6 0.14 183 −0.8 0.3 same 0.13 180 −1.2 0.2 same
intron DBP    −2.5 1.1 × 10−4    −0.7 0.4 same    −1.0 0.4 same
rs12509878 4 lncRNA C/A SBP 0.34 203 −1.5 9.8 × 10−4 0.37 183 1.3 0.03 opposite 0.37 180 −1.4 0.03 same
intron DBP    −2.2 5.8 × 10−6    1.1 0.11 opposite    −1.6 0.05 same
rs1230361 5 ERAP2 A/C SBP 0.47 204 1.4 1.1 × 10−3 0.49 183 0.5 0.4 same 0.45 180 −0.6 0.3 opposite
intron/eQTL DBP    2.1 9.3 × 10−6    0.1 0.9 same    −0.7 0.3 opposite
  1. SNPs with P < 1 × 10−5 for SBP or DBP dipping (covariate-adjusted systolic or diastolic night-to-day BP ratio using additive genetic model) in the discovery GWAS (GENRES) are shown in order of significance. Explanation for selection of related candidate gene is shown under gene name. Abbreviations: GWAS genome-wide association study, SNP single nucleotide polymorphism, Chr chromosome, EA effect allele, OA other allele, SBP systolic blood pressure, DBP diastolic blood pressure, EAF effect allele frequency, eQTL expression quantitative trait locus