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Table 4 Meta-analysis of the association of GSTM1- and GSTT1-null genotypes and GSTP1 with RCC risk and the relationship between GSTM1, GSTT1 and clinical TNM stages of RCC

From: A systematic review and meta-analyses of the relationship between glutathione S-transferase gene polymorphisms and renal cell carcinoma susceptibility

Genetic contrasts Group and subgroups Studies Number Q test P-value Model selected OR (95%CI) P
GSTM1
 - vs + Overall 15 0.23 Fixed 1.00 (0.92,1.09) 0.91
Caucasian 11 0.16 Fixed 1.02 (0.92,1.12) 0.72
Asian 3 0.23 Fixed 0.95 (0.78,1.17) 0.65
Hospital-based 11 0.43 Fixed 1.01 (0.92,1.11) 0.85
Population-based 4 0.06 Random 0.87 (0.57,1.33) 0.52
High quality 12 0.42 Fixed 1.02 (0.93,1.11) 0.72
GSTT1
 - vs + Overall 15 0.0006 Random 1.09 (0.90,1.33) 0.38
Caucasian 11 0.30 Fixed 1.00 (0.88,1.13) 0.97
Asian 3 0.005 Random 1.73 (0.91,3.28) 0.09
Hospital-based 11 0.68 Fixed 1.01 (0.90,1.14) 0.84
Population-based 4 0.01 Random 1.62 (0.90,2.91) 0.11
High quality 12 0.002 Random 1.09 (0.90,1.32) 0.39
Dual-null genotype for GSTM1/GSTT1
 - vs + Overall 9 0.08 Random 1.26 (1.00,1.59) 0.05
Caucasian 5 0.48 Fixed 1.05 (0.89,1.23) 0.58
Asian 3 0.22 Fixed 1.72 (1.24,2.38) 0.001
Hospital-based 5 0.97 Fixed 1.07 (0.91,1.25) 0.43
Population-based 4 0.12 Fixed 1.70 (1.25,2.32) 0.0007
High quality 6 0.10 Fixed 1.17 (1.01,1.36) 0.03
GSTP1
 A vs G Overall 6 0.02 Random 0.93 (0.77,1.11) 0.41
Caucasian 3 0.06 Random 1.02 (0.80,1.31) 0.85
Asian 2 0.27 Fixed 0.72 (0.58,0.90) 0.003
Hospital-based 4 0.10 Fixed 0.97 (0.87,1.08) 0.59
Population-based 2 0.02 Random 0.82 (0.52,1.29) 0.39
High quality 6 0.02 Random 0.93 (0.77,1.11) 0.41
 AA vs AG + GG Overall 8 <0.00001 Random 0.74 (0.55,1.00) 0.05
Caucasian 5 <0.00001 Random 0.72 (0.46,1.13) 0.15
Asian 2 0.19 Fixed 0.66 (0.50,0.88) 0.004
Hospital-based 6 <0.00001 Random 0.74 (0.51,1.07) 0.11
Population-based 2 0.02 Random 0.77 (0.41,1.42) 0.40
High quality 8 <0.00001 Random 0.74 (0.55,1.00) 0.05
 GG vs AG + AA Overall 6 0.22 Fixed 1.14 (0.93,1.40) 0.22
Caucasian 3 0.07 Random 0.98 (0.58,1.66) 0.95
Asian 2 0.51 Fixed 1.49 (0.90,2.49) 0.12
Hospital-based 4 0.16 Fixed 1.10 (0.87,1.40) 0.43
Population-based 2 0.21 Fixed 1.26 (0.83,1.91) 0.28
High quality 6 0.22 Fixed 1.14 (0.93,1.40) 0.22
GSTM1-TNM
 - vs + Overall 4 <0.0001 Random 0.72 (0.30,1.70) 0.45
Caucasian 1 Fixed 1.68 (0.88,3.24) 0.12
Asian 2 <0.0001 Random 0.55 (0.11,2.70) 0.46
Hospital-based 2 0.39 Fixed 1.32 (0.95,1.83) 0.10
Population-based 2 0.23 Fixed 0.30 (0.18,0.51) <0.0001
High quality 4 <0.0001 Random 0.72 (0.30,1.70) 0.45
GSTT1-TNM
 - vs + Overall 5 0.19 Fixed 0.56 (0.41,0.78) 0.0006
Caucasian 2 0.36 Fixed 0.56 (0.31,1.01) 0.06
Asian 2 0.06 Random 0.48 (0.21,1.12) 0.09
Hospital-based 3 0.55 Fixed 0.64 (0.42,0.97) 0.03
Population-based 2 0.05 Random 0.54 (0.16,1.87) 0.33
High quality 4 0.13 Fixed 0.59 (0.41,0.85) 0.004