Table 3 Characteristics of studies evaluating the effects of GSTM1 and GSTT1 null genotypes on clinical TNM stages of RCC
Gene | Author, Year | Country | Ethnicity | Source of controls | Quality | Stage I + II | Stage III + IV | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Locus | Score | – | + | Total | – | + | Total | ||||
GSTM1-TNM | Sweeney 2000 | USA | Mix | Population-based | 9 | 50 | 55 | 105 | 15 | 8 | 23 |
De Martino 2010 | Austria | Caucasian | Hospital-based | 8 | 45 | 29 | 74 | 35 | 38 | 73 | |
Ahmad 2012 | India | Asian | Population-based | 11 | 53 | 77 | 130 | 49 | 17 | 66 | |
Abid 2016 | Pakistan | Asian | Hospital-based | 8 | 77 | 115 | 192 | 93 | 168 | 261 | |
GSTT1-TNM | Sweeney 2000 | USA | Mix | Population-based | 9 | 29 | 76 | 105 | 6 | 17 | 23 |
De Martino 2010 | Austria | Caucasian | Hospital-based | 8 | 12 | 62 | 74 | 15 | 58 | 73 | |
Ahmad 2012 | India | Asian | Population-based | 11 | 72 | 58 | 130 | 53 | 13 | 66 | |
Salinas-Sanchez 2012 | Spain | Caucasian | Hospital-based | 6 | 39 | 40 | 79 | 25 | 11 | 36 | |
Abid 2016 | Pakistan | Asian | Hospital-based | 8 | 21 | 161 | 182 | 36 | 200 | 236 | |