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Table 1 Characteristics of studies evaluating the effects of GSTM1 and GSTT1 null genotypes on RCC risk

From: A systematic review and meta-analyses of the relationship between glutathione S-transferase gene polymorphisms and renal cell carcinoma susceptibility

Gene Author, Year Country Ethnicity Source of controls Quality Case Control
Locus      Score + Total + Total
GSTM1 Bruning 1997 Germany Caucasian Population-based 6 18 27 45 31 17 48
Longuemaux 1999 France Caucasian Hospital-based 8 89 84 173 117 94 211
Sweeney 2000 USA Mix Population-based 9 63 63 126 255 250 505
Buzio 2003 Italy Caucasian Hospital-based 8 50 50 100 108 92 200
Moore 2007 Europe Caucasian Hospital-based 9 424 487 911 555 677 1232
Wiesenhütter 2007 Germany Caucasian Hospital-based 8 51 47 98 167 157 324
Karami 2008 Europe Caucasian Hospital-based 9 303 321 624 433 454 887
Coric 2010 Serbia Caucasian Hospital-based 8 46 30 76 86 96 182
De Martino 2010 Austria Caucasian Hospital-based 8 80 67 147 59 53 112
Ahmad 2012 India Asian Population-based 11 102 94 196 116 134 250
Salinas-Sanchez 2012 Spain Caucasian Hospital-based 6 57 76 133 78 115 193
Jia 2014 China Asian Population-based NC 22 28 50 30 30 60
Coric 2016 Serbia Caucasian Hospital-based 8 87 109 196 137 137 274
Abid 2016 Pakistan Asian Hospital-based 8 224 378 602 171 248 419
Coric 2017 Serbia Caucasian Hospital-based 8 169 136 305 163 163 326
GSTT1 Bruning 1997 Germany Caucasian Population-based 6 3 42 45 11 37 48
Longuemaux 1999 France Caucasian Hospital-based 8 25 148 173 40 171 211
Sweeney 2000 USA Mix Population-based 9 36 90 126 93 412 505
Buzio 2003 Italy Caucasian Hospital-based 8 11 89 100 35 165 200
Moore 2007 Europe Caucasian Hospital-based 9 167 744 911 209 1023 1232
Wiesenhütter 2007 Germany Caucasian Hospital-based 8 19 79 98 59 265 324
Karami 2008 Europe Caucasian Hospital-based 9 129 499 628 161 752 913
Coric 2010 Serbia Caucasian Hospital-based 8 21 55 76 52 130 182
De Martino 2010 Austria Caucasian Hospital-based 8 27 120 147 23 89 112
Salinas-Sanchez 2012 Spain Caucasian Hospital-based 6 22 110 132 25 138 163
Ahmad 2012 India Asian Population-based 11 125 71 196 106 144 250
Jia 2014 China Asian Population-based NC 30 18 48 25 35 60
Coric 2016 Serbia Caucasian Hospital-based 8 44 152 196 71 203 274
Abid 2016 Pakistan Asian Hospital-based 8 72 482 554 49 330 379
Coric 2017 Serbia Caucasian Hospital-based 8 79 226 305 89 237 326
GSTM1-GSTT1 Bruning 1997 Germany Caucasian Population-based 6 1 44 45 6 42 48
Sweeney 2000 USA Mix Population-based 9 17 109 126 49 456 505
Moore 2007 Europe Caucasian Hospital-based 9 82 829 911 99 1133 1232
Karami 2008 Europe Caucasian Hospital-based 9 363 260 623 508 372 880
Salinas-Sanchez 2012 Spain Caucasian Hospital-based 6 7 126 133 8 185 193
Ahmad 2012 India Asian Population-based 11 71 125 196 54 196 250
Jia 2014 China Asian Population-based NC 14 34 48 10 50 60
Coric 2016 Serbia Caucasian Hospital-based 8 24 20 44 36 35 71
Abid 2016 Pakistan Asian Hospital-based 8 29 524 553 17 333 350
  1. NC not clear