Table 2 Main results of overall and subgroups in the meta-analysis
Polymorphism | Subgroup | risk allele | dominant model | recessive model | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
OR(95%CI) | P | I2 | OR(95%CI) | P | I2 | OR(95%CI) | P | I2 | ||
rs965513 | Total | 1.162 (1.117,1.208) | 0 | 94.10% | 0.87 (0.818,0.926) | 0 | 90.90% | 1.269 (1.199,1.342) | 0 | 93.80% |
Ethnicity | ||||||||||
Caucasian | 1.168 (1.122,1.215) | 0.001 | 94.9 | 0.867 (0.815,0.922) | 0 | 92.10% | 1.284 (1.213,1.359) | 0 | 94.40% | |
East Asian | 0.897 (0.680,1.193) | 0.822 | 0 | 1.424 (0.716,2.830) | 0.721 | 0.00% | 0.679 (0.448,1.029) | 0.085 | 66.40% | |
Sample size | ||||||||||
No.cases<500 | 1.320 (1.118,1.558) | 0.029 | 66.60% | 0.578 (0.403,0.83) | 0.043 | 63.20% | 1.92 (1.546,2.385) | 0 | 89.00% | |
No.cases≥500 | 1.153 (1.107,1.200) | 0 | 95.60% | 0.881 (0.827,0.938) | 0 | 92.90% | 1.231 (1.161,1.305) | 0 | 94.50% | |
rs944289 | Total | 1.082 (1.035,1.131) | 0 | 94.30% | 1.127 (1.05,1.21) | 0 | 88.60% | 0.947 (0.882,1.017) | 0 | 76.00% |
Ethnicity | ||||||||||
Caucasian | 1.067 (1.020,1.116) | 0.001 | 93.9 | 1.151 (1.070,1.237) | 0 | 84.30% | 0.948 (0.882,1.02) | 0 | 80.00% | |
East Asian | 1.764 (1.349,2.307) | 0.001 | 97.1 | 0.548 (0.356,0.845) | 0 | 96.90% | 0.892 (0.584,1.363) | 0.955 | 0.00% | |
Sample size | ||||||||||
No.cases<500 | 0.97 (0.837,1.125) | 0 | 93.90% | 1.129 (0.899,1.417) | 0 | 91.30% | 0.77 (0.604,0.981) | 0.038 | 60.60% | |
No.cases≥500 | 1.093 (1.044,1.145) | 0 | 95.00% | 1.127 (1.046,1.215) | 0 | 88.10% | 0.965 (0.896,1.04) | 0 | 81.10% | |
rs1867277 | Total | 1.415 (1.324,1.512) | 0 | 83.00% | 0.631 (0.561,0.709) | 0.012 | 63.50% | 1.583 (1.43,1.753) | 0 | 86.50% |
Ethnicity | ||||||||||
Caucasian | 1.463 (1.365,1.567) | 0.001 | 81.8 | 0.605 (0.537,0.683) | 0.114 | 46.40% | 1.644 (1.479,1.827) | 0 | 88.20% | |
East Asian | 0.957 (0.755,1.214) | 0.153 | 51.1 | 1.354 (0.791,2.318) | 0.464 | 0.00% | 0.952 (0.647,1.4) | 0.047 | 74.70% | |
Sample size | ||||||||||
No.cases<500 | 1.131 (0.945,1.353) | 0.02 | 74.40% | 0.923 (0.645,1.319) | 0.142 | 48.90% | 1.195 (0.918,1.555) | 0.008 | 79.50% | |
No.cases≥500 | 1.466 (1.365,1.574) | 0 | 85.40% | 0.601 (0.531,0.681) | 0.06 | 59.50% | 1.661 (1.487,1.856) | 0 | 90.10% | |