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Table 3 Odds ratios (OR) of the polymorphic rs5015480 HHEX genotypes for diabetesa in the population

From: Effect of smoking on the association of HHEX (rs5015480) with diabetes among Korean women and heavy smoking men

Gene    Normal Diabetes c
SNP Subjects Genotype N (%) N (%) OR (95% CIb) P-value
HHEX All TT/TC 3741 (96.9) 364(95.8) 1.00 (reference)  
rs5015480 (n = 4240) CC 119 (3.1) 16(4.2) 1.44(0.83–2.48) 0.1915
  Men TT/TC 2509 (96.8) 285(96.6) 1.00 (reference)  
   CC 83 (3.2) 10(3.4) 1.10(0.56–2.17) 0.7736
  Women TT/TC 1232 (97.2) 79(92.9) 1.00 (reference)  
   CC 36 (2.8) 6(7.1) 2.68(1.05–6.82) 0.0389
  All Healthy   2235 (97.2) 157(97.5) 1.00 (reference)  
  (n = 2461) CC 65 (2.8) 4(2.5) 0.82(0.29–2.31) 0.7035
  Men TT/TC 1426 (96.7) 121(99.2) 1.00 (reference)  
   CC 48 (3.3) 1(0.8) 0.24(0.03–1.73) 0.1545
  Women TT/TC 809 (97.9) 36(92.3) 1.00 (reference)  
   CC 17 (2.1) 3(7.7) 4.46(1.15–17.3) 0.0304
  1. aAdjusted for age and sex
  2. bCI, confidence interval
  3. cDiabetes were defined as fasting serum glucose ≥126 mg/dL or medication
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BMC Medical Genetics

ISSN: 1471-2350

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