Influence of maternal and own genotype at tanning dependence-related SNPs on sun exposure in childhood

BMC Medical Genetics

Table 3 Association of tanning dependent related single nucleotide polymorphisms and sun exposure variables

SNP (RA)	Outcome	Partly adjusted				Fully adjusted
SNP (RA)	Outcome	OR	95% CI	p	n	OR	95% CI	p	n
Childs SNPs
rs60050811 (C)	Usually used sun block or cream when out in the sun at age 8 years	1.34	1.11–1.62	.0025	4983	1.43	1.09–1.88	.0106	3438
Mothers SNPs
rs650662 (A)	Factor of sun block or cream the child usually used at age 8 years ^a	0.89	0.82–0.96	.0020	4524	0.89	0.81–0.99	.0291	3459
rs2073478 (T)	Star system rating of child’s sun block or cream ^b	0.68	0.53–0.88	.0028	741	0.68	0.49–0.94	.0181	585
Analyses adjusted for sex and pigmentation
Childs SNPs
rs60050811 (C)	Usually used sun block or cream when out in the sun at age 8 years	1.43	1.01–1.87	.0074	2549	1.29	0.90–1.86	.2651	1892
Mothers SNPs
rs650662 (A)	Factor of sun block or cream the child usually used at age 8 years^a	0.86	0.77–0.96	.0057	2385	0.88	0.77–1.01	.0627	1919
rs2073478 (T)	Star system rating of child’s sun block or cream ^b	0.58	0.40–0.82	.0021	416	0.58	0.38–0.89	.0131	338

RA Risk allele (increases the risk of becoming TD, allele used based on findings from Cartmel et al. [13]); SNP Single nucleotide polymorphism
The partly adjusted model adjusted for the mothers’ or child’s principal components (1–8 in the mother’s and child’s analysis respectively), and the age of the child (in months) when the questionnaire was completed. The fully adjusted model was adjusted for both the child and mother’s SNPs and principal components (1–2) and the age of the child (in months) when the questionnaire was completed
^a 0 = factor 0–7; 1 = factor 8–14; 2 = factor 15–20; 3 = factor 21–25; 4 = 25+
^b 0 = star rating 1–3, 1 = star rating 4

ISSN: 1471-2350