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Table 2 Cox regression model: Adjusted risk of cardiac events at the age of 18–40 years in LQT1 and LQT2 patients before initiation of β-blocker medicationa

From: Clinical and molecular genetic risk determinants in adult long QT syndrome type 1 and 2 patients

 

Hazard ratio

95% confidence interval

P-value

LQT2 vs LQT1

2.11

1.33–3.34

0.002

Female vs male

3.18

1.71–5.91

< 0.001

CE vs no CE before age 18

5.93

3.72–9.44

< 0.001

QTc ≥500 vs < 470 ms

2.66

1.53–4.64

0.001

QTc ≥500 vs 470–499 ms

2.22

1.23–4.00

0.01

QTc 470–499 vs < 470 ms

1.20

0.71–2.04

0.50

  1. aPatients with > 1 LQTS-causing mutation (n = 7) are excluded
  2. The model was adjusted for family membership using robust sandwich estimators
  3. A separate QTc missing covariate was used for patients whose QTc data were unavailable (n = 35)
  4. CE: cardiac event
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BMC Medical Genetics

ISSN: 1471-2350

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