Table 2 IVDD-Control allele and genotype frequency comparison
Cytokine | Position | Alleles/ Genotypes | IVDD | Control | Hardy-Weinberg equilibrium X2 P value | P-Value | OR | 95% CI |
|---|---|---|---|---|---|---|---|---|
(N = 76) | (N = 140) | |||||||
N (%) | N (%) | |||||||
TGF-β | Codon 10 | C | 76 (50) | 131 (47.5) | – | 0.69 | 1.11 | 0.74–1.65 |
T | 76 (50) | 145 (52.5) | – | 0.69 | 0.90 | 0.60–1.35 | ||
CC | 13 (17.1) | 20 (14.5) | 5.81 (0.015) | 0.69 | 1.22 | 0.57–2.61 | ||
CT | 50 (65.8) | 91 (65.9) | 1.00 | 0.99 | 0.55–1.79 | |||
TT | 13 (17.1) | 27 (19.6) | 0.72 | 0.85 | 0.41–1.76 | |||
TGF-β | Codon 25 | C | 12 (8) | 21 (7.6) | – | 1.00 | 1.06 | 0.50–2.21 |
G | 138 (92) | 255 (92.4) | – | 1.00 | 0.94 | 0.45–2.00 | ||
CC | 1 (1.3) | 2 (1.5) | 2.12 (0.14) | 1.00 | 0.92 | 0.08–10.30 | ||
GC | 10 (13.3) | 17 (12.3) | 1.00 | 1.09 | 0.47–2.53 | |||
GG | 64 (85.3) | 119 (86.2) | 1.00 | 0.93 | 0.42–2.07 | |||
IL-10 | -1082 | A | 93 (61.2) | 181 (64.6) | – | 0.53 | 0.86 | 0.57–1.29 |
G | 59 (38.8) | 99 (35.4) | – | 0.53 | 1.16 | 0.77–1.75 | ||
AA | 19 (25) | 53 (37.8) | 4.14 0.041) | 0.07 | 0.55 | 0.29–1.02 | ||
GA | 55 (72.4) | 75 (53.6) | 0.009 | 2.27 | 1.24–4.15 | |||
GG | 2 (2.6) | 12 (8.6) | 0.15 | 0.29 | 0.06–1.32 | |||
IL-10 | -819 | C | 88 (57.9) | 199 (71.1) | – | 0.008 | 0.56 | 0.37–0.85 |
T | 64 (42.1) | 81 (28.9) | – | 0.008 | 1.78 | 1.17–2.70 | ||
CC | 20 (26.3) | 71 (50.7) | 0.01 (0.92) | 0.001 | 0.35 | 0.19–0.64 | ||
CT | 48 (63.2) | 57 (40.7) | 0.002 | 2.49 | 1.40–4.44 | |||
TT | 8 (10.5) | 12 (8.6) | 0.81 | 1.25 | 0.49–3.22 | |||
IL-10 | -592 | A | 73 (48) | 81 (28.9) | – | 0.000 | 2.27 | 1.51–3.42 |
C | 79 (52) | 199 (71.1) | – | 0.000 | 0.44 | 0.29–0.66 | ||
AA | 9 (11.8) | 12 (8.6) | 15.36 (<0.0001) | 0.47 | 1.43 | 0.57–3.57 | ||
CA | 55 (72.4) | 57 (40.7) | 0.000 | 3.81 | 2.08–6.98 | |||
CC | 12 (15.8) | 71 (50.7) | 0.000 | 0.18 | 0.09–0.37 |