|
STAT3 polymorphism
|
Patients (n = 567)
|
Resolvers (n = 98)
|
Controls (n = 169)
|
Patients vs. Resolvers
|
Patients vs. Controls
|
|---|
|
P
|
OR (95%CI)
|
P
|
OR (95%CI)
|
|---|
|
rs1053004
|
|
Genotype
|
|
TT
|
266 (46.9)
|
42 (42.9)
|
88 (52.1)
|
Ref.
| |
Ref.
| |
|
TC
|
235 (41.4)
|
42 (42.9)
|
76 (45.0)
|
0.599
|
0.883 (0.556–1.403)
|
0.900
|
0.978 (0.686–1.392)
|
|
CC
|
66 (11.6)
|
14 (14.2)
|
5 (2.9)
|
0.381
|
0.744 (0.384–1.443)
|
0.001 a
|
4.367 (1.705–11.185)
|
|
Allele
|
|
T
|
767 (67.6)
|
126 (64.3)
|
252 (74.6)
|
Ref.
| |
Ref.
| |
|
C
|
367 (32.3)
|
70 (35.7)
|
86 (25.4)
|
0.356
|
0.861 (0.627–1.183)
|
0.019 b
|
1.402 (1.065–1.845)
|
|
rs1053005
|
|
Genotype
|
|
AA
|
271 (47.8)
|
44 (44.9)
|
84 (49.7)
|
Ref.
| |
Ref.
| |
|
AG
|
239 (42.2)
|
41 (41.8)
|
78 (46.2)
|
0.814
|
1.057 (0.667–1.673)
|
0.775
|
0.950 (0.667–1.353)
|
|
GG
|
57 (10.0)
|
13 (13.3)
|
7 (4.1)
|
0.327
|
0.712 (0.360–1.407)
|
0.023c
|
2.524 (1.109–5.744)
|
|
Allele
|
|
A
|
781(68.9)
|
129 (65.8)
|
246 (72.8)
|
Ref.
| | | |
|
G
|
353 (31.1)
|
67 (34.2)
|
92 (27.2)
|
0.208
|
0.870 (0.631–1.199)
|
0.170
|
1.209 (0.922–1.584)
|
|
Haplotype (rs1053004- rs1053005)
|
|
T-A
|
767 (67.7)
|
126 (64.8)
|
246 (72.8)
|
Ref.
| |
Ref.
| |
|
C-G
|
353 (31.1)
|
67 (34.2)
|
86 (25.4)
|
0.379
|
0.866 (0.627–1.194)
|
0.059
|
1.316 (0.999–1.735)
|
|
T-G
|
0 (0)
|
0 (0)
|
6 (1.8)
|
1.000
|
1.000 (1.000–1.000)
|
< 0.001d
|
0.243 (0.218–0.271)
|
|
C-A
|
14 (1.2)
|
3 (1.0)
|
0 (0)
|
0.950
|
1.304 (0.370–4.604)
|
0.034e
|
1.321 (1.275–1.368)
|
- Data are presented as n (%). OR odds ratio, 95%CI 95% confidence interval, Ref. reference. a P value by Bonferroni correction = 0.002; bP value by Bonferroni correction = 0.019; cP value by Bonferroni correction = 0.046; dP value by Bonferroni correction< 0.001; eP value by Bonferroni correction = 0.102
