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Table 2 Genotype, allele and haplotype frequencies of STAT3 rs1053004 and rs1053005 polymorphisms in patients with chronic hepatitis B virus (HBV) infection, HBV infection resolvers and healthy controls

From: Association of polymorphism rs1053005 in STAT3 with chronic hepatitis B virus infection in Han Chinese population

STAT3 polymorphism Patients (n = 567) Resolvers (n = 98) Controls (n = 169) Patients vs. Resolvers Patients vs. Controls
P OR (95%CI) P OR (95%CI)
rs1053004
 Genotype
  TT 266 (46.9) 42 (42.9) 88 (52.1) Ref.   Ref.  
  TC 235 (41.4) 42 (42.9) 76 (45.0) 0.599 0.883 (0.556–1.403) 0.900 0.978 (0.686–1.392)
  CC 66 (11.6) 14 (14.2) 5 (2.9) 0.381 0.744 (0.384–1.443) 0.001 a 4.367 (1.705–11.185)
 Allele
  T 767 (67.6) 126 (64.3) 252 (74.6) Ref.   Ref.  
  C 367 (32.3) 70 (35.7) 86 (25.4) 0.356 0.861 (0.627–1.183) 0.019 b 1.402 (1.065–1.845)
rs1053005
 Genotype
  AA 271 (47.8) 44 (44.9) 84 (49.7) Ref.   Ref.  
  AG 239 (42.2) 41 (41.8) 78 (46.2) 0.814 1.057 (0.667–1.673) 0.775 0.950 (0.667–1.353)
  GG 57 (10.0) 13 (13.3) 7 (4.1) 0.327 0.712 (0.360–1.407) 0.023c 2.524 (1.109–5.744)
 Allele
  A 781(68.9) 129 (65.8) 246 (72.8) Ref.    
  G 353 (31.1) 67 (34.2) 92 (27.2) 0.208 0.870 (0.631–1.199) 0.170 1.209 (0.922–1.584)
Haplotype (rs1053004- rs1053005)
 T-A 767 (67.7) 126 (64.8) 246 (72.8) Ref.   Ref.  
 C-G 353 (31.1) 67 (34.2) 86 (25.4) 0.379 0.866 (0.627–1.194) 0.059 1.316 (0.999–1.735)
 T-G 0 (0) 0 (0) 6 (1.8) 1.000 1.000 (1.000–1.000) < 0.001d 0.243 (0.218–0.271)
 C-A 14 (1.2) 3 (1.0) 0 (0) 0.950 1.304 (0.370–4.604) 0.034e 1.321 (1.275–1.368)
  1. Data are presented as n (%). OR odds ratio, 95%CI 95% confidence interval, Ref. reference. a P value by Bonferroni correction = 0.002; bP value by Bonferroni correction = 0.019; cP value by Bonferroni correction = 0.046; dP value by Bonferroni correction< 0.001; eP value by Bonferroni correction = 0.102