MiR-146a G/C rs2910164 variation in South African Indian and Caucasian patients with psoriatic arthritis

BMC Medical Genetics

Table 3 Genotype and allele frequencies for PsA patients and controls before and after stratification for race (Indians and Caucasians)

Frequency, n (%)	Controls	PsA patients	p value	RR (95% CI)	OR (95% CI)
Unstratified: Indians + Caucasians (PsA patients: n = 116 and controls: n = 100)
Genotype, n (%)
GG	52 (52)	43 (37.07)	0.0595^a1
GC	44 (44)	63 (54.31)
CC	4 (4)	10 (8.62)
GC + CC	48 (48)	73 (62.93)	0.0290^b	1.38 (1.04–1.84)	1.84 (1.07–3.17)
Allele, n (%)
G	148 (74)	149 (64.22)	0.0295^c	1.29 (1.02–1.65)	1.59 (1.05–2.40)
C	52 (26)	83 (35.78)	0.0295^c	1.29 (1.02–1.65)	1.59 (1.05–2.40)
Stratified: Indians (PsA patients: n = 84 and controls: n = 62)
Genotype, n (%)
GG	37 (59.68)	31 (36.90)	0.0241^a2
GC	22 (35.48)	46 (54.76)
CC	3 (4.84)	7 (8.33)
GC + CC	25 (40.32)	53 (63.10)	0.0075^b	1.70 (1.15–2.51)	2.53 (1.29–4.96)
Allele, n (%)
G	96 (77.41)	108 (64.29)	0.0200^c	1.48 (1.05–2.08)	1.91 (1.13–3.22)
C	28 (22.58)	60 (35.71)	0.0200^c	1.48 (1.05–2.08)	1.91 (1.13–3.22)
Stratified: Caucasians (PsA patients: n = 32 and controls: n = 38)
Genotype, n (%)
GG	15 (39.47)	12 (37.50)	0.4793^a3
GC	22 (57.89)	17 (53.13)
CC	1 (2.63)	3 (9.38)
GC + CC	23 (60.52)	20 (62.5)	0.9383^b	1.04 (0.67–1.61)	1.09 (0.41–2.86)
Allele, n (%)
G	52 (68.42)	41 (64.06)	0.5955^c	1.10 (0.78–1.53)	1.22 (0.60–2.46)
C	24 (31.58)	23 (35.04)	0.5955^c	1.10 (0.78–1.53)	1.22 (0.60–2.46)

CI confidence interval, DF degrees of freedom, RR relative risk, OR odds ratio, PsA psoriatic arthritis, χ² Chi-squared test
^{a1, a2, a3}Chi squared p value (controls genotypes vs. PsA patients genotypes) (^a1 χ² = 5.644, 2 DF; ^a2 χ² = 7.454, 2 DF; ^a3 χ² = 1.471, 2 DF). ^bFisher’s exact test p value (GG vs. GC + CC genotypes). ^cFisher’s exact test p value (controls G and C alleles vs. PsA patients G and C alleles). A p < 0.05 was considered as being significant

ISSN: 1471-2350