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Fig. 5 | BMC Medical Genetics

Fig. 5

From: Compound heterozygous variants in the multiple PDZ domain protein (MPDZ) cause a case of mild non-progressive communicating hydrocephalus

Fig. 5

A comparison of the intracellular localization of the wild type MPDZ protein and both mutants. a Myc-tagged wild-type (Wt) MPDZ protein. b Myc-tagged (p.Gly132Ser) MPDZ protein. c Myc-tagged (p.Leu582Val) MPDZ protein. They were immunostained with anti Myc antibodies (red). Cells were co-transfected with GFP-H-Ras plasmid (green) which localizes at cell membrane. Images reveal that the wild-type protein, as well as both mutant proteins (red) co-localize largely and similarly with GFP-H-Ras at the plasma membrane, in addition to the localization of MPDZ in the cytosol

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