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Table 3 Genotype and allele distributions of MMP1, 3, and 12 polymorphisms

From: Association of matrix metalloprotease 1, 3, and 12 polymorphisms with rheumatic heart disease in a Chinese Han population

Gene (polymorphism) RHD
n (%)
Controls
n (%)
p value OR (95% CI)
MMP1 (rs1799750)
 Genotype    0.072*  
  1G/1G 6 (6.7) 15 (16.7) (Ref.)
  1G/2G 43 (47.8) 44 (48.9) 0.09 2.455 (0.87–6.926)
  2G/2G 41 (45.6) 31 (34.4) 0.03 3.227 (1.118–9.31)
 Allele
  1G 55 (30.6) 74 (41.1) (Ref.)
  2G 125 (69.4) 106 (58.9) 0.048 0.644 (0.416–0.996)
MMP3 (rs3025058)
 Genotype    0.509*  
  6A/6A 65 (72.2) 67 (74.4) (Ref.)
  5A/6A 21 (23.3) 22 (24.4) 0.983 0.993 (0.498–1.981)
  5A/5A 4 (4.4) 1 (1.1) 0.230 3.908 (0.421–36.242)
 Allele
  6A 151 (83.9) 156 (86.7) (Ref.)
  5A 29 (16.1) 24 (13.3) 0.473 1.24 (0.689–2.231)
MMP12 (rs2276109)
 Genotype    0.767*  
  A/A 85 (94.4) 83 (92.2) (Ref.)
  A/G 5 (5.6) 7 (7.8) 0.569 0.708 (0.215–2.324)
  G/G 0 (0.0) 0 (0.0)
 Allele
  A 175 (97.2) 173 (96.1) (Ref.)
  G 5 (2.8) 7 (3.9) 0.576 0.717 (0.223–2.307)
  1. The genotype and allele with p < 0.05 are shown in bold fonts
  2. OR odds ratio, CI confidence interval, and Ref. reference
  3. *p value calculated from 2 × 3 contingency table