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Table 3 Genotype and allele distributions of MMP1, 3, and 12 polymorphisms

From: Association of matrix metalloprotease 1, 3, and 12 polymorphisms with rheumatic heart disease in a Chinese Han population

Gene (polymorphism)

RHD

n (%)

Controls

n (%)

p value

OR (95% CI)

MMP1 (rs1799750)

 Genotype

  

0.072*

 

  1G/1G

6 (6.7)

15 (16.7)

–

(Ref.)

  1G/2G

43 (47.8)

44 (48.9)

0.09

2.455 (0.87–6.926)

  2G/2G

41 (45.6)

31 (34.4)

0.03

3.227 (1.118–9.31)

 Allele

  1G

55 (30.6)

74 (41.1)

–

(Ref.)

  2G

125 (69.4)

106 (58.9)

0.048

0.644 (0.416–0.996)

MMP3 (rs3025058)

 Genotype

  

0.509*

 

  6A/6A

65 (72.2)

67 (74.4)

–

(Ref.)

  5A/6A

21 (23.3)

22 (24.4)

0.983

0.993 (0.498–1.981)

  5A/5A

4 (4.4)

1 (1.1)

0.230

3.908 (0.421–36.242)

 Allele

  6A

151 (83.9)

156 (86.7)

–

(Ref.)

  5A

29 (16.1)

24 (13.3)

0.473

1.24 (0.689–2.231)

MMP12 (rs2276109)

 Genotype

  

0.767*

 

  A/A

85 (94.4)

83 (92.2)

–

(Ref.)

  A/G

5 (5.6)

7 (7.8)

0.569

0.708 (0.215–2.324)

  G/G

0 (0.0)

0 (0.0)

–

–

 Allele

  A

175 (97.2)

173 (96.1)

–

(Ref.)

  G

5 (2.8)

7 (3.9)

0.576

0.717 (0.223–2.307)

  1. The genotype and allele with p < 0.05 are shown in bold fonts
  2. OR odds ratio, CI confidence interval, and Ref. reference
  3. *p value calculated from 2 × 3 contingency table