Fig. 5
From: A novel compound heterozygous variant of the SLC12A3 gene in Gitelman syndrome pedigree
Effect of SLC12A3 mutations on the modeled structure of the Na-Cl cotransporter (NCC) protein. Compared to the wild-type (a), c.1919A > G (b) alone caused three visible differences in the protein structure (marked with red and black frames), whereas c.2522A > G (c) alone led to one further difference (marked with a brown frame). Coexistence of c.1919A > G and c.2522A > G (d) resulted in three more differences (marked with purple frames)