Receptor-Ligand | Hydrogen Bonding | Hydrophobic Interactions | Figure | ||
---|---|---|---|---|---|
Ligand Residues | Receptor Residues | Ligand Residues | Receptor Residues | ||
TCIRG1- ATPV1B1 | Gly40 | Tyr583 | Thr12 Tyr13 Ile14 Ser15 Pro17 Phe20 Thr39 Arg41 Val50 Ser51 Ile57 Glu61 Glu62 Thr63 Gly65 Leu66 Ala69 Thr70 | His409 Met420 Val421 Leu422 His526 Leu527 Asn531 Met535 His559 Phe560 Leu580 Ohe581 Leu584 Ile589 | Fig. 5a |
Mutant TCIRG1- ATPV1B1 | Asp2Ala69 | Cys2Arg28Asp54 | Glu7 Gly10 Ala24 Lys25 Leu27 Ala28 Try29 Gly30 Ala31 Val33 Asp34 Ile35 Val42 Gly44 Gly45 Gln46 Tyr54 Val59 Glu61 Leu68 Thr70 Ser72 Ser74 Leu75 | Val13 Gln14 Leu15 Phe16 Gln48 Arg50 Arg57 Cys58 Leu61 Phe65 Pro81 Pro82 Lys83 Gly84 Arg85 Pro87 Arg92 | Fig. 5b |