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Table 2 Additive genetic model of inheritance (per copy allele frequency) for association of 24 SNPs previously associated with atrial fibrillation, and in this study investigated for association with ventricular fibrillation before ST-segment elevation myocardial infarction

From: Association of common genetic variants related to atrial fibrillation and the risk of ventricular fibrillation in the setting of first ST-elevation myocardial infarction

  Locus SNP RA RAF (Cases/Controls) OR 95% CI P Nearest gene symbol
1& 1q21 rs6666258 C 0.31/0.33 0.91 0.72–1.15 0.400 KCNN3 [9, 26]
2 1q24 rs3903239 C 0.46/0.49 0.85 0.68–1.07 0.200 PRRX1 [9]
3 3p25 rs4642101 G 0.61/0.62 0.99 0.79–1.25 0.900 CAND2 [22]
4#* 3p21 rs6795970 A 0.00/0.00 – – – SCN10A [17]
5&* 4q25 rs2200733 T 0.08/0.08 0.96 0.65–1.42 0.900 PITX2 [9, 10]
6& 4q25 rs2634073 A 0.14/0.15 0.88 0.65–1.20 0.400 PITX2 [9]
7& 4q25 rs6843082 G 0.16/0.18 0.87 0.66–1.17 0.400 PITX2 [9, 14]
8 4q25 rs1448818 G 0.26/0.24 1.13 0.89–1.43 0.300 PITX2 [21]
9& 4q25 rs10033464 T 0.76/0.94 0.79 0.53–1.17 0.300 PITX2 [21, 27]
10 4q25 rs17570669 T 0.06/0.08 0.74 0.48–1.12 0.200 PITX2 [21]
11 4q25 rs2723288 T 0.29/0.28 1.08 0.86–1.35 0.500 PITX2 [21]
12 4q25 rs4400058 A 0.08/0.09 0.80 0.54–1.18 0.300 PITX2 [21]
13 4q25 rs6838973 T 0.43/0.44 0.95 0.76–1.18 0.700 PITX2 [21]
14 4q25 rs3853445 C 0.26/0.25 0.99 0.78–1.27 0.900 PITX2 [21]
15 5q31 rs2040862 T 0.18/0.16 1.15 0.87–1.53 0.300 PITX2 [21]
16 6q22 rs13216675 T 0.68/0.69 0.95 0.75–1.18 0.600 GJA1 [22]
17 7q31 rs3807989 G 0.41/0.42 1.00 0.81–1.25 0.900 CAV1 [9]
18 9q22 rs10821415 A 0.39/0.39 0.97 0.78–1.20 0.800 C9ORF3 [9]
19 10q22 rs10824026 G 0.13/0.15 0.85 0.62–1.16 0.300 MYOZ1 [9]
20 10q24 rs12415501 T 0.15/0.16 0.92 0.68–1.23 0.600 NEURL [22]
21 12q24 rs10507248 T 0.75/0.74 1.05 0.82–1.33 0.700 TBX5 [22]
22 14q23 rs1152591 T 0.51/0.48 1.11 0.89–1.38 0.300 SYNE2 [9]
23 15q24 rs7164883 G 0.17/0.13 1.28 0.96–1.70 0.090 HCN4 [9]
24 16q22 rs2106261 A 0.18/0.17 1.09 0.83–1.44 0.500 ZFHX3 [9, 36]
  1. SNP: single-nucleotide polymorphism; RA: Risk allele; RAF: Risk allele frequency in cases over controls in our cohort; OR: odds ratio; CI: confidence interval; P value for the additive genetic model of inheritance (per copy allele frequency)
  2. #: No risk allele (A) exists in the GEVAMI cohort. Logistic regression models under an additive model of inheritance adjusted for age and sex. Number of cases = 257; number of controls = 537
  3. &: The SNP rs6666258 is in linkage disequilibrium (r2 = 1.00) with rs13376333
  4. &: The SNP 2200733 is in linkage disequilibrium (r2 = 1.00) with rs6817105 and rs17042171
  5. &: The rs2634073 is in linkage disequilibrium (r2 = 0.80) with rs6843082
  6. &: The rs10033464 is in linkage disequilibrium (r2 = 1.00) with rs4032974
  7. *: The SNP rs6795970 and 2,200,733 are both associated with SCD [20]
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