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Table 2 Additive genetic model of inheritance (per copy allele frequency) for association of 24 SNPs previously associated with atrial fibrillation, and in this study investigated for association with ventricular fibrillation before ST-segment elevation myocardial infarction

From: Association of common genetic variants related to atrial fibrillation and the risk of ventricular fibrillation in the setting of first ST-elevation myocardial infarction

 

Locus

SNP

RA

RAF (Cases/Controls)

OR

95% CI

P

Nearest gene symbol

1&

1q21

rs6666258

C

0.31/0.33

0.91

0.72–1.15

0.400

KCNN3 [9, 26]

2

1q24

rs3903239

C

0.46/0.49

0.85

0.68–1.07

0.200

PRRX1 [9]

3

3p25

rs4642101

G

0.61/0.62

0.99

0.79–1.25

0.900

CAND2 [22]

4#*

3p21

rs6795970

A

0.00/0.00

–

–

–

SCN10A [17]

5&*

4q25

rs2200733

T

0.08/0.08

0.96

0.65–1.42

0.900

PITX2 [9, 10]

6&

4q25

rs2634073

A

0.14/0.15

0.88

0.65–1.20

0.400

PITX2 [9]

7&

4q25

rs6843082

G

0.16/0.18

0.87

0.66–1.17

0.400

PITX2 [9, 14]

8

4q25

rs1448818

G

0.26/0.24

1.13

0.89–1.43

0.300

PITX2 [21]

9&

4q25

rs10033464

T

0.76/0.94

0.79

0.53–1.17

0.300

PITX2 [21, 27]

10

4q25

rs17570669

T

0.06/0.08

0.74

0.48–1.12

0.200

PITX2 [21]

11

4q25

rs2723288

T

0.29/0.28

1.08

0.86–1.35

0.500

PITX2 [21]

12

4q25

rs4400058

A

0.08/0.09

0.80

0.54–1.18

0.300

PITX2 [21]

13

4q25

rs6838973

T

0.43/0.44

0.95

0.76–1.18

0.700

PITX2 [21]

14

4q25

rs3853445

C

0.26/0.25

0.99

0.78–1.27

0.900

PITX2 [21]

15

5q31

rs2040862

T

0.18/0.16

1.15

0.87–1.53

0.300

PITX2 [21]

16

6q22

rs13216675

T

0.68/0.69

0.95

0.75–1.18

0.600

GJA1 [22]

17

7q31

rs3807989

G

0.41/0.42

1.00

0.81–1.25

0.900

CAV1 [9]

18

9q22

rs10821415

A

0.39/0.39

0.97

0.78–1.20

0.800

C9ORF3 [9]

19

10q22

rs10824026

G

0.13/0.15

0.85

0.62–1.16

0.300

MYOZ1 [9]

20

10q24

rs12415501

T

0.15/0.16

0.92

0.68–1.23

0.600

NEURL [22]

21

12q24

rs10507248

T

0.75/0.74

1.05

0.82–1.33

0.700

TBX5 [22]

22

14q23

rs1152591

T

0.51/0.48

1.11

0.89–1.38

0.300

SYNE2 [9]

23

15q24

rs7164883

G

0.17/0.13

1.28

0.96–1.70

0.090

HCN4 [9]

24

16q22

rs2106261

A

0.18/0.17

1.09

0.83–1.44

0.500

ZFHX3 [9, 36]

  1. SNP: single-nucleotide polymorphism; RA: Risk allele; RAF: Risk allele frequency in cases over controls in our cohort; OR: odds ratio; CI: confidence interval; P value for the additive genetic model of inheritance (per copy allele frequency)
  2. #: No risk allele (A) exists in the GEVAMI cohort. Logistic regression models under an additive model of inheritance adjusted for age and sex. Number of cases = 257; number of controls = 537
  3. &: The SNP rs6666258 is in linkage disequilibrium (r2 = 1.00) with rs13376333
  4. &: The SNP 2200733 is in linkage disequilibrium (r2 = 1.00) with rs6817105 and rs17042171
  5. &: The rs2634073 is in linkage disequilibrium (r2 = 0.80) with rs6843082
  6. &: The rs10033464 is in linkage disequilibrium (r2 = 1.00) with rs4032974
  7. *: The SNP rs6795970 and 2,200,733 are both associated with SCD [20]