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Table 4 Genotype distribution under dominant and recessive models and allele frequencies of the rs1799983, Intron 4 VNTR and rs2070744 in patients and control groups

From: Association of NOS3 gene polymorphisms with essential hypertension in Sudanese patients: a case control study

  Patients n(%) Controls n(%)  
rs1799983 Dominant model GG 99 (67.3%) 60 (73.2%) χ2 = 0.84
P = 0.36
OR (95% CI) = 0.76 (0.42–1.4)
GT + TT 48 (32.7%) 22 (26.8%)
Recessive model GG + GT 142 (96.6%) 80 (97.6%) χ2 = 0.17
P = 0.69
OR (95% CI) = 0.71 (0.14–3.74)
TT 5 (3.4%) 2 (2.4%)
Allele frequency G 242 (82.3%) 140 (85.4%) χ2 = 0.71
P = 0.40
OR (95% CI) = 0.80 (0.47–1.35)
T 52 (17.7%) 24 (14.6%)
Intron 4 VNTR Dominant model bb 144 (95.4%) 75 (96.2%) χ2 = 0.08
P = 0.78
OR (95% CI) = 0.82(0.21–3.3)
ab + aa 7 (4.6%) 3 (3.8%)
Recessive model bb + ab 83 (55%) 50 (64.1%) χ2 = 1.76
P = 0.18
OR (95% CI) = 0.68 (0.39–1.2)
aa 68 (45%) 28 (35.9%)
Allele frequency b 227 (75.2%) 125 (80.1%) χ2 = 1.42
P = 0.23
OR (95% CI) = 1.33 (0.83–2.14)
a 75 (24.8%) 31 (19.9%)
rs2070744 Dominant model TT 72 (47.4%) 54 (65.9%) χ2 = 7.32
P = 0.007
OR (95% CI) = 2.14 (1.23–3.74)
TC + CC 80 (52.6%) 28 (34.1%)
Recessive model TT + TC 142 (93.4%) 78 (95.1%) χ2 = 0.27
P = 0.60
OR (95% CI) = 0.73 (0.22–2.4)
CC 10 (6.6%) 4 (4.9%)
Allele frequency T 214 (70.4%) 131 (79.9%) χ2 = 4.95
P = 0.03
OR (95% CI) = 1.84 (1.15–2.93)
C 90 (29.6%) 33 (20.1%)
  1. Binary logistic regressions were tested for all the three polymorphisms with age, gender and smoking as covariates and none had an effect on the genotype distribution under dominant and recessive models