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Table 4 Genotype distribution under dominant and recessive models and allele frequencies of the rs1799983, Intron 4 VNTR and rs2070744 in patients and control groups

From: Association of NOS3 gene polymorphisms with essential hypertension in Sudanese patients: a case control study

 

Patients n(%)

Controls n(%)

 

rs1799983

Dominant model

GG

99 (67.3%)

60 (73.2%)

χ2 = 0.84

P = 0.36

OR (95% CI) = 0.76 (0.42–1.4)

GT + TT

48 (32.7%)

22 (26.8%)

Recessive model

GG + GT

142 (96.6%)

80 (97.6%)

χ2 = 0.17

P = 0.69

OR (95% CI) = 0.71 (0.14–3.74)

TT

5 (3.4%)

2 (2.4%)

Allele frequency

G

242 (82.3%)

140 (85.4%)

χ2 = 0.71

P = 0.40

OR (95% CI) = 0.80 (0.47–1.35)

T

52 (17.7%)

24 (14.6%)

Intron 4 VNTR

Dominant model

bb

144 (95.4%)

75 (96.2%)

χ2 = 0.08

P = 0.78

OR (95% CI) = 0.82(0.21–3.3)

ab + aa

7 (4.6%)

3 (3.8%)

Recessive model

bb + ab

83 (55%)

50 (64.1%)

χ2 = 1.76

P = 0.18

OR (95% CI) = 0.68 (0.39–1.2)

aa

68 (45%)

28 (35.9%)

Allele frequency

b

227 (75.2%)

125 (80.1%)

χ2 = 1.42

P = 0.23

OR (95% CI) = 1.33 (0.83–2.14)

a

75 (24.8%)

31 (19.9%)

rs2070744

Dominant model

TT

72 (47.4%)

54 (65.9%)

χ2 = 7.32

P = 0.007

OR (95% CI) = 2.14 (1.23–3.74)

TC + CC

80 (52.6%)

28 (34.1%)

Recessive model

TT + TC

142 (93.4%)

78 (95.1%)

χ2 = 0.27

P = 0.60

OR (95% CI) = 0.73 (0.22–2.4)

CC

10 (6.6%)

4 (4.9%)

Allele frequency

T

214 (70.4%)

131 (79.9%)

χ2 = 4.95

P = 0.03

OR (95% CI) = 1.84 (1.15–2.93)

C

90 (29.6%)

33 (20.1%)

  1. Binary logistic regressions were tested for all the three polymorphisms with age, gender and smoking as covariates and none had an effect on the genotype distribution under dominant and recessive models
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BMC Medical Genetics

ISSN: 1471-2350

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