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Table 2 Distribution of genotype and allele frequencies of the PGR + 331G/A variation

From: No association between the progesterone receptor gene polymorphism (+331G/a) and the risk of breast cancer: an updated meta-analysis

 

Genotype distribution

 

Allele frequency

 

Cases, n

 

Controls, n

 

Cases, %

 

Controls, %

Author

GG

AG

AA

 

GG

AG

AA

P HWE

G

A

 

G

A

De Vivo

864

126*

  

1218

139*

 

–

–

–

 

–

–

Diergaarde

294

29*

  

580

70*

 

–

–

–

 

–

–

Feigelson

425

53

1

 

445

48

1

0.8039

94.3

5.7

 

94.9

5.1

Fernandez

508

36

0

 

509

43

1

0.9266

97.0

3.0

 

96.0

4.0

Huggins

1134

164*

  

1560

168*

 

–

–

–

 

–

–

Jin

182

24

0

 

199

15

0

0.5952

94.0

6.0

 

96.0

4.0

Johnatt

1282

161*

  

474

56*

 

–

–

–

 

–

–

Kotsopoulos

1463

195

6

 

2174

202

15

<0.0001

94.0

6.0

 

95.0

5.0

Pearce

1596

76

2

 

2317

113

2

0.6086

97.6

2.4

 

97.6

2.4

Pooley

1929

253

5

 

2002

260

7

0.6379

94.0

6.0

 

94.0

6.0

Reding

1128

161*

  

910

111*

 

–

–

–

 

–

–

Romano

476

48

11

 

339

37

3

0.0874

93.0

7.0

 

94.0

6.0

Romano

153

15

1

 

25

5

1

0.2781

95.0

5.0

 

88.7

11.3

  1. P HWE the P value of Hardy-Weinberg equilibrium test in the genotype distribution of controls, *For these just presenting the genotyping of AG + AA, dominant model is calculated only
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BMC Medical Genetics

ISSN: 1471-2350

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