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Table 1 Time course of the phenotype in the proband

From: Non-syndromic cardiac progeria in a patient with the rare pathogenic p.Asp300Asn variant in the LMNA gene

Year

Age

Phenotype

Intervention

1994

29

Acute myocardial infarction

Coronary Artery bypass surgery

1995

30

Mitral regurgitation

Mitral valve repair surgery

2001

36

Acute myocardial infarction

Percutaneous coronary interventions

2001

36

Sick Sinus Syndrome

Permanent pacemaker implantation

2001

36

Aortic and mitral valves stenosis/regurgitation

Aortic valve replacement

Mitral valve replacement

2003

38

Atrial flutter

Catheter ablation

2004

39

Acute myocardial infarction

Percutaneous coronary interventions, placement of 2 stents

2004

39

Refractory right heart failure with severe tricuspid regurgitation

Transplant evaluation

2005

40

Death