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Table 3 Scale for methodological quality assessment

From: Lack of associations of the opioid receptor mu 1 (OPRM1) A118G polymorphism (rs1799971) with alcohol dependence: review and meta-analysis of retrospective controlled studies

Criteria

Score

1. Representativeness of cases

 

 RA diagnosed according to acknowledged criteria.

2

 Mentioned the diagnosed criteria but not specifically described.

1

 Not Mentioned.

0

2. Source of controls

 

 Population or community based

3

 Hospital-based RA-free controls

2

 Healthy volunteers without total description

1

 RA-free controls with related diseases

0.5

 Not described

0

3. Sample size

 

  > 300

2

 200–300

1

  < 200

0

4. Quality control of genotyping methods

 

 Repetition of partial/total tested samples with a different method

2

 Repetition of partial/total tested samples with the same method

1

 Not described

0

5. Hardy-Weinberg equilibrium (HWE)

 

 Hardy-Weinberg equilibrium in control subjects

1

 Hardy-Weinberg disequilibrium in control subjects

0