Table 2 Gene-gene interaction analysis
From: Analysis of SNP-SNP interactions and bone quantitative ultrasound parameter in early adulthood
SNP1 | Gene 1 | SNP2 | Gene 2 | β (95% CI) | p-value |
|---|---|---|---|---|---|
rs9340799 | ESR1 | rs3736228 | LRP5 | 14.289 (5.548, 23.029) | 0.001 |
rs2908004 | WNT16 | rs3801387 | WNT16 | 77.350 (25.890, 128.808) | 0.003 |
rs597319 | TMEM135 | rs2908004 | WNT16 | 9.101 (2.498, 15.704) | 0.007 |
rs3736228 | LRP5 | rs2306862 | LRP5 | 23.476 (5.623, 41.327) | 0.010 |
rs9340799 | ESR1 | rs7902708 | DKK1 | 13.641 (2.959, 24.322) | 0.012 |
rs4355801 | OPG | rs556442 | LRP5 | 8.724 (1.936, 15.512) | 0.012 |
rs3801387 | WNT16 | rs2982552 | ESR1 | −8.705 (−15.554, −1.855) | 0.013 |
rs556442 | LRP5 | rs9340799 | ESR1 | 9.859 (2.045, 17.673) | 0.013 |
rs11898505 | SPTBN1 | rs10416265 | GPATCH1 | −9.200 (−16.751, −1.649) | 0.017 |
rs2982552 | ESR1 | rs3020331 | ESR1 | 13.312 (2.242, 24.381) | 0.018 |
rs2148073 | RANKL | rs1805034 | RANK | 8.443 (1.127, 15.758) | 0.023 |
rs4869739 | CCDC170 | rs7741021 | RSPO3 | −7.748 (−14.501, −0.995) | 0.024 |
rs2234693 | ESR1 | rs3736228 | LRP5 | 10.606 (1.361, 19.851) | 0.024 |
rs556442 | LRP5 | rs12458117 | RANK | −9.760 (−18.261, −1.258) | 0.024 |
rs3801387 | WNT16 | rs4355801 | OPG | 7.333 (0.887, 13.777) | 0.025 |
rs2306862 | LRP5 | rs9340799 | ESR1 | 8.239 (0.973, 15.504) | 0.026 |
rs2982552 | ESR1 | rs9340799 | ESR1 | 9.322 (1.037, 17.606) | 0.027 |
rs7902708 | DKK1 | rs4355801 | OPG | −8.159 (−15.383, −0.934) | 0.027 |
rs2306862 | LRP5 | rs4355801 | OPG | 7.779 (0.888, 14.668) | 0.027 |
rs2306862 | LRP5 | rs11898505 | SPTBN1 | 7.989 (0.793, 15.183) | 0.029 |
rs556442 | LRP5 | rs2234693 | ESR1 | 7.449 (0.664, 14.233) | 0.031 |
rs3801385 | WNT16 | rs2982552 | ESR1 | −11.658 (−22.351, −0.965) | 0.032 |
rs9340799 | ESR1 | rs7741021 | RSPO3 | 7.191 (0.409, 13.973) | 0.037 |
rs597319 | TMEM135 | rs851054 | SOST | 6.828 (0.405, 13.25) | 0.037 |
rs2148073 | RANKL | rs10416265 | GPATCH1 | −7.879 (−15.478, −0.278) | 0.042 |
rs597319 | TMEM135 | rs2908007 | WNT16 | 6.889 (0.197, 13.579) | 0.043 |
rs3801387 | WNT16 | rs12458117 | RANK | 7.949 (0.192, 15.704) | 0.044 |
rs2234693 | ESR1 | rs3801385 | WNT16 | 13.418 (0.273, 26.562) | 0.045 |
rs3018362 | RANK | rs10416265 | GPATCH1 | 7.359 (0.114, 14.604) | 0.046 |
rs12458117 | RANK | rs7741021 | RSPO3 | −7.388 (−14.744, −0.031) | 0.048 |
rs2908004 | WNT16 | rs4355801 | OPG | 7.273 (0.014, 14.530) | 0.049 |