Skip to main content

Table 2 Meta analysis of the association of VDR BsmI,FokI, TaqI and ApaI gene polymorphisms with DN risk

From: Vitamin D receptor gene polymorphisms in association with diabetic nephropathy: a systematic review and meta-analysis

Genetic Group and Studies Q test p Model OR(95%CI) p
contrasts subgroups number value selected
BsmI
B vs b Overall 3 0.06 Random 1.13 [0.72, 1.75] 0.60
  Caucasian 2 0.39 Fixed 0.99 [0.85, 1.16] 0.93
  Asian 1 - Fixed 1.75 [1.08, 2.86] 0.02
BB vs Bb + bb Overall 3 0.38 Fixed 0.98 [0.74, 1.30] 0.89
  Caucasian 2 0.36 Fixed 0.96 [0.72, 1.28] 0.77
  Asian 1 - Fixed 4.78 [0.24, 93.31] 0.30
bb vs BB + Bb Overall 3 0.11 Random 0.84 [0.53, 1.33] 0.45
  Caucasian 2 0.55 Fixed 0.99 [0.79, 1.24] 0.93
  Asian 1 - Fixed 0.55 [0.32, 0.94] 0.03
FokI
F vs f Overall 4 0.0001 Random 0.88 [0.52, 1.48] 0.62
  Caucasian 3 0.04 Random 1.19 [0.81, 1.73] 0.38
  Asian 1 - Fixed 0.33 [0.18, 0.61] 0.0004
FF vs Ff + ff Overall 4 0.004 Random 0.92 [0.50, 1.71] 0.80
  Caucasian 3 0.05 Random 1.24 [0.74, 2.05] 0.41
  Asian 1 - Fixed 0.29 [0.12, 0.72] 0.008
ff vs FF + Ff Overall 4 0.005 Random 1.18 [0.52, 2.72] 0.69
  Caucasian 3 0.18 Fixed 0.78 [0.59, 1.03] 0.08
  Asian 1 - Fixed 5.00 [1.61, 15.56] 0.005
TaqI
T vs t Overall 4 0.20 Fixed 0.96 [0.84, 1.11] 0.62
  Caucasian 2 0.89 Fixed 0.92 [0.79, 1.08] 0.30
  Asian 2 0.09 Random 1.46 [0.63, 3.38] 0.37
TT vs Tt + tt Overall 4 0.15 Fixed 0.97 [0.79, 1.20] 0.77
  Caucasian 2 0.95 Fixed 0.89 [0.71, 1.11] 0.31
  Asian 2 0.89 Fixed 2.21 [1.05, 4.67] 0.04
tt vs TT + Tt Overall 4 0.68 Fixed 1.08 [0.83, 1.40] 0.56
  Caucasian 2 0.89 Fixed 1.10 [0.82, 1.48] 0.52
  Asian 2 0.22 Fixed 1.01 [0.58, 1.77] 0.97
ApaI
A vs a Overall 4 0.44 Fixed 0.94 [0.83, 1.07] 0.35
  Caucasian 1 - Fixed 0.97 [0.84, 1.13] 0.73
  Asian 3 0.33 Fixed 0.89 [0.72, 1.10] 0.26
AA vs Aa + aa Overall 4 0.14 Fixed 0.89 [0.72, 1.11] 0.31
  Caucasian 1 - Fixed 0.93 [0.74, 1.18] 0.57
  Asian 3 0.06 Fixed 0.73 [0.43, 1.23] 0.24
aa vs AA + Aa Overall 4 0.79 Fixed 1.06 [0.87, 1.28] 0.58
  Caucasian 1 - Fixed 0.99 [0.77, 1.29] 0.96
  Asian 3 0.75 Fixed 1.14 [0.85, 1.53] 0.37
\