Skip to main content

Table 1 Characteristics of the studies evaluating the effects of VDR BsmI,FokI, TaqI and ApaI gene polymorphisms on DN risk

From: Vitamin D receptor gene polymorphisms in association with diabetic nephropathy: a systematic review and meta-analysis

Gene Author Ethnicity Country Type of DM Sex Case Control HWE(p)
sites year male/female
BsmI       BB Bb bb Total BB Bb bb Total  
  Bućan 2009 Caucasian Croatia DM1 —/— 1 8 5 14 6 18 9 33 0.566
  Martin 2009 Caucasian Ireland DM1 Case 359/296 106 321 228 655 111 325 238 674 0.998
  Control 286/388
  Zhang 2012 Asian China DM2 Case 99/83 Control 68/54 3 57 122 182 0 26 96 122 0.188
FokI       FF Ff ff Total FF Ff ff Total  
  Li 2005 Asian China DM2 30/64 9 17 13 39 28 22 5 55 0.821
  Bućan 2009 Caucasian Croatia DM1 —/— 4 6 4 14 9 18 6 33 0.566
  Martin 2009 Caucasian Ireland DM1 Case 359/296 Control 286/388 248 323 84 655 262 311 101 674 0.580
  Vedralová 2012 Caucasian Czech DM1/2 Case 75/57 Control 94/76 63 58 11 132 57 85 28 170 0.696
TaqI       TT Tt tt Total TT Tt tt Total  
  Bućan 2009 Caucasian Croatia DM1 —/— 5 6 3 14 13 14 6 33 0.522
  Martin 2009 Caucasian Ireland DM1 Case 359/296 Control 286/388 103 327 225 655 98 327 249 674 0.575
  Nosratabadi 2010 Asian Iran DM2 Case 38/62 Control 41/59 9 55 36 100 4 63 33 100 0
  Han 2015 Asian China DM2 150/138 102 6 0 108 160 16 4 180 0
ApaI       AA Aa aa Total AA Aa aa Total  
  Martin 2009 Caucasian Ireland DM1 Case 359/296 Control 286/388 185 323 147 655 200 322 152 674 0.303
  Nosratabadi 2010 Asian Iran DM2 Case 38/62 Control 41/59 9 64 27 100 9 63 28 100 0.002
  Zhang 2012 Asian China DM2 Case 99/83 Control 68/54 19 89 74 182 11 65 46 122 0.075
  Han 2015 Asian China DM2 150/138 2 50 56 108 18 80 82 180 0.814
\