Vitamin D receptor gene polymorphisms in association with diabetic nephropathy: a systematic review and meta-analysis

Table 1 Characteristics of the studies evaluating the effects of VDR BsmI,FokI, TaqI and ApaI gene polymorphisms on DN risk

Gene	Author	Ethnicity	Country	Type of DM	Sex	Case				Control				HWE(p)
sites	year	Ethnicity	Country	Type of DM	male/female	Case				Control				HWE(p)
BsmI						BB	Bb	bb	Total	BB	Bb	bb	Total
	Bućan 2009	Caucasian	Croatia	DM1	—/—	1	8	5	14	6	18	9	33	0.566
	Martin 2009	Caucasian	Ireland	DM1	Case 359/296	106	321	228	655	111	325	238	674	0.998
	Martin 2009	Caucasian	Ireland	DM1	Control 286/388	106	321	228	655	111	325	238	674	0.998
	Zhang 2012	Asian	China	DM2	Case 99/83 Control 68/54	3	57	122	182	0	26	96	122	0.188
FokI						FF	Ff	ff	Total	FF	Ff	ff	Total
	Li 2005	Asian	China	DM2	30/64	9	17	13	39	28	22	5	55	0.821
	Bućan 2009	Caucasian	Croatia	DM1	—/—	4	6	4	14	9	18	6	33	0.566
	Martin 2009	Caucasian	Ireland	DM1	Case 359/296 Control 286/388	248	323	84	655	262	311	101	674	0.580
	Vedralová 2012	Caucasian	Czech	DM1/2	Case 75/57 Control 94/76	63	58	11	132	57	85	28	170	0.696
TaqI						TT	Tt	tt	Total	TT	Tt	tt	Total
	Bućan 2009	Caucasian	Croatia	DM1	—/—	5	6	3	14	13	14	6	33	0.522
	Martin 2009	Caucasian	Ireland	DM1	Case 359/296 Control 286/388	103	327	225	655	98	327	249	674	0.575
	Nosratabadi 2010	Asian	Iran	DM2	Case 38/62 Control 41/59	9	55	36	100	4	63	33	100	0
	Han 2015	Asian	China	DM2	150/138	102	6	0	108	160	16	4	180	0
ApaI						AA	Aa	aa	Total	AA	Aa	aa	Total
	Martin 2009	Caucasian	Ireland	DM1	Case 359/296 Control 286/388	185	323	147	655	200	322	152	674	0.303
	Nosratabadi 2010	Asian	Iran	DM2	Case 38/62 Control 41/59	9	64	27	100	9	63	28	100	0.002
	Zhang 2012	Asian	China	DM2	Case 99/83 Control 68/54	19	89	74	182	11	65	46	122	0.075
	Han 2015	Asian	China	DM2	150/138	2	50	56	108	18	80	82	180	0.814

ISSN: 1471-2350