Table 3 Top 50 known genes downregulated in IIP patients

PRB2

Proline rich protein BstNI subfamily 2

8.35E-04

DEFA3

Defensin alpha 3

9.05E-04

DEFA1

Defensin alpha 1

1.09E-03

PRB1

Proline rich protein BstNI subfamily 1

1.21E-03

HLA-DRB5

Major histocompatibility complex, class II, DR beta 5

1.38E-03

CYP1A2

Cytochrome P450 family 1 subfamily A member 2

1.59E-03

VNN2

Vanin 2

1.73E-03

MUC7

Mucin 7

1.82E-03

PRB3

Proline rich protein BstNI subfamily 3

1.85E-03

FPR2

Formyl peptide receptor 2

1.88E-03

WDR47

WD repeat domain 47

1.90E-03

HLA-C

Major histocompatibility complex, class I, C

1.91E-03

HIST1H2BD

Histone cluster 1 H2B family member d

1.94E-03

CCRL1

Chemokine (C-C motif) receptor-like 1

2.00E-03

UMOD

Uromodulin

2.09E-03

HIST1H1E

Histone cluster 1 H1 family member e

2.11E-03

HIST1H2AE

Histone cluster 1 H2A family member e

2.19E-03

FCAR

Fc fragment of IgA receptor

2.24E-03

SLCO1A2

Solute carrier organic anion transporter family member 1A2

2.26E-03

RNASE3

Ribonuclease A family member 3

2.27E-03

WWP2

WW domain containing E3 ubiquitin protein ligase 2

2.33E-03

BPIFB2

BPI fold containing family B member 2

2.34E-03

LPO

Lactoperoxidase

2.40E-03

ITLN1

Intelectin 1

2.42E-03

NAIP

NLR family apoptosis inhibitory protein

2.42E-03

CCDC85A

Coiled-coil domain containing 85A

2.46E-03

MAP4

Microtubule associated protein 4

2.50E-03

PRH2

Proline rich protein HaeIII subfamily 2

2.54E-03

IL10

Interleukin 10

2.59E-03

CELA2A

Chymotrypsin like elastase family member 2A

2.63E-03

RGPD1

RANBP2-like and GRIP domain containing 1

2.64E-03

LAT2

Linker for activation of T-cells family member 2

2.66E-03

LRCH1

Leucine rich repeats and calponin homology domain containing 1

2.67E-03

HFE

Hemochromatosis

2.79E-03

GPM6A

Glycoprotein M6A

2.81E-03

APOL1

Apolipoprotein L1

2.84E-03

FCGR3B

Fc fragment of IgG receptor IIIb

2.89E-03

S100A12

S100 calcium binding protein A12

2.92E-03

CCK

Cholecystokinin

2.93E-03

FCRL6

Fc receptor like 6

2.94E-03

OPRPN

Opiorphin prepropeptide

2.96E-03

HMGCS2

3-hydroxy-3-methylglutaryl-CoA synthase 2

2.98E-03

C8orf37

chromosome 8 open reading frame 37

3.02E-03

TCN1

Transcobalamin 1

3.06E-03

HIST1H4I

Histone cluster 1 H4 family member i

3.11E-03

SLC22A12

Solute carrier family 22 member 12

3.14E-03

RGPD5

RANBP2-like and GRIP domain containing 5

3.26E-03

PRTG

Protogenin

3.32E-03

C8B

Complement C8 beta chain

3.38E-03

CLEC4M

C-type lectin domain family 4 member M

3.46E-03