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Table 2 Top 50 genes upregulated in idiopathic interstitial pneumonia (IIP) patients

From: Gene expression profiling of idiopathic interstitial pneumonias (IIPs): identification of potential diagnostic markers and therapeutic targets

Gene symbol

Gene name

Fold change

Fibrotic IIP/control

DSG3

Desmoglein 3

321.2

KLRD1

Killer cell lectin-like receptor subfamily D, member 1

252.8

OTUB1

OTU domain, ubiquitin aldehyde binding 1

246.7

ZFP92

ZFP92 zinc finger protein

222.9

NLGN4Y

Neuroligin 4, Y-linked

217.2

GLB1L3

Galactosidase, beta 1-like 3

214.8

CDC25C

Cell division cycle 25C

211.4

CNTNAP3B

Contactin-associated protein-like 3B

186.3

SRGAP2

SLIT-ROBO Rho GTPase-activating protein 2

174.5

NEK3

NIMA-related kinase 3

167.0

SYT8

Synaptotagmin VIII

156.9

TLR10

Toll-like receptor 10

145.6

DST

Dystonin

140.3

COL7A1

Collagen type VII, alpha 1

139.4

UTY

Ubiquitously transcribed tetratricopeptide repeat-containing, Y-linked

127.8

CYorf15A

Chromosome Y open reading frame 15A

121.8

PCDHGA9

Protocadherin gamma subfamily A, 9

120.9

OXTR

Oxytocin receptor

111.8

AIM2

Absent in melanoma 2

107.5

TMSB4Y

Thymosin beta 4, Y-linked

106.4

YBEY

ybeY metallopeptidase

104.4

UBE2D2

Ubiquitin-conjugating enzyme E2D 2

102.7

DDR1

Discoidin domain receptor tyrosine kinase 1

99.2

ZFY

Zinc finger protein, Y-linked

98.0

SLC17A9

Solute carrier family 17, member 9

98.0

EIF1AY

Eukaryotic translation initiation factor 1A, Y-linked

96.8

ANO9

Anoctamin 9

91.6

DDX3Y

DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked

88.7

HBS1L

HBS1-like (S. cerevisiae)

88.6

MSL3

Male-specific lethal 3 homolog (D. melanogaster)

85.2

MUC1

Mucin 1, cell surface-associated

83.3

PLCH2

Phospholipase C, eta 2

82.5

LPGAT1

Lysophosphatidylglycerol acyltransferase 1

81.8

DDX6

DEAD (Asp-Glu-Ala-Asp) box helicase 6

80.4

SDK2

sidekick cell adhesion molecule 2

79.2

C1QTNF1

C1q and tumor necrosis factor related protein 1

78.8

ZRANB2

zinc finger, RAN-binding domain containing 2

78.6

ZNF300

zinc finger protein 300

76.9

DMBT1

deleted in malignant brain tumors 1

76.7

GFI1B

growth factor independent 1B transcription repressor

75.1

SLFN13

schlafen family member 13

72.1

CDK5RAP3

CDK5 regulatory subunit associated protein 3

70.8

SLCO3A1

solute carrier organic anion transporter family, member 3A1

70.5

SNRNP70

small nuclear ribonucleoprotein 70 kDa (U1)

66.2

IL18BP

interleukin 18 binding protein

64.7

PCNXL2

pecanex-like 2 (Drosophila)

64.6

ZSCAN29

zinc finger and SCAN domain containing 29

63.7

ESR2

estrogen receptor 2 (ER beta)

62.5

FBXO41

F-box protein 41

61.7

MRPL20

mitochondrial ribosomal protein L20

61.3