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Table 7 Most of the BRCA2 mutations variants detected within African literature

From: Monoallelic characteristic-bearing heterozygous L1053X in BRCA2 gene among Sudanese women with breast cancer

BRCA2 variants   Country Ref.
c. 2826_2829delAATT   South Africa van der Merwe NC, et al. 2012 [57]
c. 5771_5774delTTCA  
c. 6448dupTA  
c. 7934delG Founder-
c.5946delT  
C.8162delG   Schoeman M, et al. 2013 [58]
c.5999del4  
c.6174delT  
c.582G > A   Francies FZ, et al. 2015 [59]
c.5771_5774delTTCA  
c.5213_5216delCTTA  
c.8754 + 1G > A  
c.9097_9098insA  
c.4798_4800delAAT  
c.7712A > G  
c.9875C > T  
c.7934delG founder founder Afrikaner population of South Africa Seymour HJ, et al.2016 [60]
c.6621delA   South Africa
c.6761_6762delTT  
c.5073dupA   Morocco LAARABI FZ, et al.2011 [61]
c.3381delT   Tazzite A, et al. 2012 [62]
c.7110delA  
c.7235insG  
c.517-1G > A  
c.6428 C > A   Guaoua S, et al.2014 [63]
c.745-1G > A   Jouhadi H, et al.2016 [64]
c.5682insA   Tunisia Troudi W, et al. 2007 [65]
c.1309del4  
c.-25G > A  
c.6301 A > C  
c.1595 A > T  
c.7242 A > G  
c.865 A > G  
c.1310_1313del (1538delAAGA)   Fourati A, et al. 2014 [66]
c.-26G > A   Riahi A, et al.2014 [67]
c.681 + 56C > T  
c.793 + 65_793 + 65delT  
C.8503 T > C  
5456delGTAGCA   Hadiji-Abbes N,et al. 2015 [68]
c.1313dupT   Riahi A, et al.2015 [69]
c.7654dupT  
c.67 + 62 T > G  
c.8487 + 47C > T  
c.8360G > A  
c.8830A > T  
c.9875C > T  
c.10240A > G  
c.8182G > A  
c.8503 T > C  
c.1542_1547delAAGA   Riahi A, et al. 2017 [70]
c.5682insA  
c.1309del4  
c.1310 1313delAAGA   Algeria Cherbal F, et al. 2010 [71]
c.5722 5723delCT  
c.67 + 14 T > C  
c.67 + 15 T > C  
c.68–14 T > A  
c.68-21 T > G  
c.231 T > G  
c.3555A > T  
c.3868 T > A  
c.5553C > T  
c.5472 T > G  
c.5592C > A  
c.5976A > G  
c.5985C > A  
c.8487 + 19A > C  
c.68-16 T > A   Cherbal F, et al.2012 [72]
c.475 + 25A > G  
c.794-5A > T  
c.1099G > A  
c.2636C > A  
c.2657A > G  
c.2673C > G  
c.5397A > T  
c.5428G > T  
c.6309A > C  
c.6346C > G  
c.9256G > A  
c.7654dupA   Henouda S, et al.2016 [73]
c.1528G > T  
Del exons 19–20  
c.6450del  
c.7462A > G  
c.1504A > C  
c.5939C > T  
c.1627C > A  
c.3195_3198delTAAT   Sudan Awadelkarim KD, et al.2007 [16]
c.6406_6407delTT  
c.8642_8643insTTTT  
c.122C > T  
c.6101G > A  
c.68-7delT  
999TCAAA deleted (999del5)   Egypt Bensam M, et al.2014 [74]
2256 T > C  
8934G > A  
c.970G > A   Nigeria Fackenthal JD, et al.2005 [49]
c.1093A > C  
c.1503A > G  
c.2366 A > T  
c.3014 T > C  
c. 3188A > T  
c. 3199A > G  
c. 3492 T > C  
c. 4299A > C  
c. 4469C > T  
c. 4791G > A  
c. 5646A > G  
c. 5932G > A  
c. 5938C > G  
c. 6741C > G  
c. 7378C > A  
c. 7470A > G  
c. 7547A > G  
c. 9058A > T  
c. 9862G > C  
3034delACAA  
ex2-11C > T  
ex7-19C > T  
ex11-43 T > C  
ex12-200insC  
ex17-40A > G  
ex18 + 109G > A  
ex21-36C > G  
ex22-70C > T  
ex26 + 106delT  
1538delAAGA c.1310_1313delAAGA   Zhang J, et al.2012 [75]
1222delA   Fackenthal JD, et al.2012 [76]
2630del11  
3036delACAA  
4157delC  
5358delTGTA  
5369delATTT  
5469insTA  
5581delAC  
7482delAG  
9045delGAAA  
Q3066X