Polymorphism rs189037C > T in the promoter region of the ATM gene may associate with reduced risk of T2DM in older adults in China: a case control study

Table 3 Genotype distributions of the ATM rs189037 and the association with T2DM in males (n = 112)

	T2DM group (n = 56)	Control group (n = 56)	χ²	P value
Genotypes, n (%)
CC	22 (39.3)	11 (19.6)	6.20	0.045^*
CT	23 (41.1)	35 (62.5)
TT	11 (19.6)	10 (17.9)
Allele, %
C	59.8	50.9	1.81	0.179
	OR (95%CI)		P value
CC versus others^a
Unadjusted	0.38 (0.16–0.88)		0.025^*
Adjusted	2.78 (0.88–8.79)		0.082
CT versus others^b
Unadjusted	0.42 (0.20–0.89)		0.024^*
Adjusted	0.27 (0.09–0.84)		0.024^*
TT versus others^c
Unadjusted	1.12 (0.44–2.91)		0.809
Adjusted	1.87 (0.48–7.25)		0.368

^a: CT and TT; ^b: CC and TT; ^c: CC and CT. OR Odds ratio, CI Confidence interval. T2DM Type 2 diabetes mellitus, FPG Fasting plasma glucose, UA Uric acid, TG Triglycerides, TC Total cholesterol, LDL-C Low-density lipoprotein cholesterol, HDL-C High-density lipoprotein cholesterol, CAD Coronary artery disease
*: P < 0.05

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