Polymorphism rs189037C > T in the promoter region of the ATM gene may associate with reduced risk of T2DM in older adults in China: a case control study

Table 2 Genotypes distributions of ATM rs189037 and the association with T2DM (n = 160)

	T2DM group (n = 80)	Control group (n = 80)	χ²	P value
Genotypes, n (%)
CC	28 (35.0)	17 (21.3)	6.60	0.037^*
CT	32 (40.0)	48 (60.0)
TT	20 (25.0)	15 (18.7)
C allele frequency, %	55.0	51.3	0.45	0.501
	OR (95%CI)		P value
CC versus others^a
Unadjusted	0.50 (0.25–1.02)		0.055
Adjusted	1.61 (0.62–4.18)		0.332
CT versus others^b
Unadjusted	0.44 (0.24–0.84)		0.012^*
Adjusted	2.62 (1.05–6.53)		0.038^*
TT versus others^c
Unadjusted	1.44 (0.68–3.08)		0.340
Adjusted	0.46 (0.16–1.31)		0.146

^a: CT and TT; ^b: CC and TT; ^c: CC and CT. OR Odds ratio, CI Confidence interval. T2DM Type 2 diabetes mellitus, FPG Fasting plasma glucose, UA Uric acid, TG Triglycerides, TC Total cholesterol, LDL-C Low-density lipoprotein cholesterol, HDL-C High-density lipoprotein cholesterol, CAD Coronary artery disease
^*: P < 0.05

ISSN: 1471-2350