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Table 4 In silico protein prediction effect of DAND5 p.Arg152His alteration

From: Functional study of DAND5 variant in patients with Congenital Heart Disease and laterality defects

 

Score

Prediction effect

PolyPhen-2

0,120

Benign

Mutation Taster

Polymorphism

Might affect protein features

PROVEAN

-2,84 (cutoff = −2,5)

Deleterious

I-Mutant 3.0

−1,28 Kcal/mol

Reduced stability of the protein and related to disease