Table 4 Association of candidate SNP loci with type 2 diabetes in the age-matched Kazakh study cohorts
SNP | Gene | Major/ Minor allele | Minor allele frequency | Odds ratio (95% CI) | P-value | |
|---|---|---|---|---|---|---|
Control (n = 141) | T2DM (n = 223) | |||||
rs3751812 | FTO | G/T | 0.24 | 0.29 | 1.41 (0.97–2.07) | 0.07 |
rs8050136 | FTO | C/A | 0.25 | 0.3 | 1.37 (0.94–2.01) | 0.09 |
rs9939609 | FTO | T/A | 0.23 | 0.29 | 1.52 (1.03–2.26) |  0.04 |
rs10811661 | CDKN2A/B | T/C | 0.23 | 0.24 | 1.03 (0.71–1.50) | 0.86 |
rs2383208 | CDKN2A/B | A/G | 0.22 | 0.22 | 0.99 (0.67–1.48) | 0.96 |
rs1111875 | HHEX | T/C | 0.38 | 0.42 | 1.19 (0.87–1.64) | 0.26 |
rs13266634 | SLC30A8 | C/T | 0.4 | 0.32 | 0.68 (0.49–0.93) | 0.02 |
rs4506565 | TCF7L2 | A/T | 0.16 | 0.19 | 1.22 (0.82–1.84) | 0.34 |
rs5215 | KCNJ11 | T/C | 0.33 | 0.36 | 1.15 (0.83–1.59) | 0.4 |
rs7756992 | CDKAL1 | A/G | 0.31 | 0.33 | 1.11 (0.79–1.56) | 0.55 |
rs4712523 | CDKAL1 | A/G | 0.3 | 0.34 | 1.18 (0.85–1.65) | 0.31 |
rs9465871 | CDKAL1 | T/C | 0.29 | 0.31 | 1.07 (0.76–1.51) | 0.67 |
rs7961581 | near TSPAN8/LGR5 | T/C | 0.21 | 0.29 | 1.54 (1.05–2.27) | 0.03 |
rs864745 | JAZF1 | T/C | 0.38 | 0.39 | 1.04 (0.77–1.43) | 0.76 |
rs12779790 | near CDC123/CAMK1D | A/G | 0.18 | 0.16 | 0.89 (0.55–1.44) | 0.64 |
rs10490072 | BCL11A | T/C | 0.12 | 0.12 | 0.96 (0.57–1.61) | 0.88 |
rs10923931 | NOTCH2 | G/T | 0.05 | 0.07 | 1.56 (0.77–3.34) | 0.22 |
rs7578597 | THADA | T/C | 0.06 | 0.05 | 0.91 (0.46–1.80) | 0.78 |
rs2025804 | LEPR | A/G | 0.67 | 0.6 | 0.76 (0.55–1.06) | 0.12 |
rs2641348 | ADAM30 | A/G | 0.04 | 0.07 | 1.85 (0.90–4.14) | 0.11 |
rs9472138 | near VEGFA | C/T | 0.19 | 0.2 | 1.05 (0.71–1.58) | 0.79 |
rs1042714 | ADRB2 | C/G | 0.31 | 0.3 | 0.97 (0.68–1.37) | 0.87 |
rs4994 | ADRB3 | A/G | 0.16 | 0.19 | 1.16 (0.76–1.78) | 0.48 |
rs1799883 | FABP2 | C/T | 0.3 | 0.39 | 1.51 (1.06–2.13) | 0.02 |
rs1801282 | PPARG | C/G | 0.11 | 0.13 | 1.23 (0.78–2.00) | 0.37 |
rs8192678 | PPARGC1A | C/T | 0.36 | 0.32 | 0.82 (0.59–1.15) | 0.26 |
rs780094 | GCKR | C/T | 0.4 | 0.38 | 0.9 (0.58–1.39) | 0.63 |
rs7944584 | MADD | A/T | 0.11 | 0.15 | 1.46 (0.77–2.98) | 0.26 |