Skip to main content

Table 4 Association of candidate SNP loci with type 2 diabetes in the age-matched Kazakh study cohorts

From: Association between 28 single nucleotide polymorphisms and type 2 diabetes mellitus in the Kazakh population: a case-control study

SNP Gene Major/ Minor allele Minor allele frequency Odds ratio (95% CI) P-value
Control (n = 141) T2DM (n = 223)
rs3751812 FTO G/T 0.24 0.29 1.41 (0.97–2.07) 0.07
rs8050136 FTO C/A 0.25 0.3 1.37 (0.94–2.01) 0.09
rs9939609 FTO T/A 0.23 0.29 1.52 (1.03–2.26)  0.04
rs10811661 CDKN2A/B T/C 0.23 0.24 1.03 (0.71–1.50) 0.86
rs2383208 CDKN2A/B A/G 0.22 0.22 0.99 (0.67–1.48) 0.96
rs1111875 HHEX T/C 0.38 0.42 1.19 (0.87–1.64) 0.26
rs13266634 SLC30A8 C/T 0.4 0.32 0.68 (0.49–0.93) 0.02
rs4506565 TCF7L2 A/T 0.16 0.19 1.22 (0.82–1.84) 0.34
rs5215 KCNJ11 T/C 0.33 0.36 1.15 (0.83–1.59) 0.4
rs7756992 CDKAL1 A/G 0.31 0.33 1.11 (0.79–1.56) 0.55
rs4712523 CDKAL1 A/G 0.3 0.34 1.18 (0.85–1.65) 0.31
rs9465871 CDKAL1 T/C 0.29 0.31 1.07 (0.76–1.51) 0.67
rs7961581 near TSPAN8/LGR5 T/C 0.21 0.29 1.54 (1.05–2.27) 0.03
rs864745 JAZF1 T/C 0.38 0.39 1.04 (0.77–1.43) 0.76
rs12779790 near CDC123/CAMK1D A/G 0.18 0.16 0.89 (0.55–1.44) 0.64
rs10490072 BCL11A T/C 0.12 0.12 0.96 (0.57–1.61) 0.88
rs10923931 NOTCH2 G/T 0.05 0.07 1.56 (0.77–3.34) 0.22
rs7578597 THADA T/C 0.06 0.05 0.91 (0.46–1.80) 0.78
rs2025804 LEPR A/G 0.67 0.6 0.76 (0.55–1.06) 0.12
rs2641348 ADAM30 A/G 0.04 0.07 1.85 (0.90–4.14) 0.11
rs9472138 near VEGFA C/T 0.19 0.2 1.05 (0.71–1.58) 0.79
rs1042714 ADRB2 C/G 0.31 0.3 0.97 (0.68–1.37) 0.87
rs4994 ADRB3 A/G 0.16 0.19 1.16 (0.76–1.78) 0.48
rs1799883 FABP2 C/T 0.3 0.39 1.51 (1.06–2.13) 0.02
rs1801282 PPARG C/G 0.11 0.13 1.23 (0.78–2.00) 0.37
rs8192678 PPARGC1A C/T 0.36 0.32 0.82 (0.59–1.15) 0.26
rs780094 GCKR C/T 0.4 0.38 0.9 (0.58–1.39) 0.63
rs7944584 MADD A/T 0.11 0.15 1.46 (0.77–2.98) 0.26
  1. All SNPs are analyzed in additive model. Logistic regression models were used adjusted for age and sex. Bold and italic P-values are statistically significant with P < 0.05