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Table 1 Characteristic of selected SNPs

From: Association between 28 single nucleotide polymorphisms and type 2 diabetes mellitus in the Kazakh population: a case-control study

SNP ID Gene or nearby region Location Position Traits OR [95% CI] References
rs3751812 FTO 16q12.2 Intron 1 Obesity 1.42 [1.33–1.52] Frayling et al., 2007 [60]
rs8050136 FTO 16q12.2 Intron 1 T2DM; obesity 1.22 [1.07–1.40] 1.45 [1.09–1.93] Liu et al., 2010 [26]
rs9939609 FTO 16q12.2 Intron 1 T2DM; obesity 1.19 [1.04–1.37]; 1.39 [1.04–1.85] Liu et al., 2010 [26]
rs10811661 CDKN2A/B 9p21.3 Intergenic T2DM 1.20 [1.14–1.25] Zeggini et al., 2007 [27]
rs2383208 CDKN2A/B 9p21.3 Intergenic T2DM 1.34 [1.27–1.41] Takeuchi et al., 2009 [28]
rs1111875 HHEX 10q23.33 3′-UTR T2DM 1.21 [1.15–1.28] Takeuchi et al., 2009 [28]
rs5015480 HHEX 10q23.33 Intergenic T2DM 1.17 [1.11–1.24] Zegginietal., 2008
rs13266634 SLC30A8 8q24.11 Exon 8, missense T2DM 1.16 [1.10–1.22] Rung et al., 2009 [29], Takeuchi et al., 2009 [28]
rs4506565 TCF7L2 10q25.3 Intron 3 T2DM 1.36 [1.20–1.54] Wellcome Trust Case Control Consortium (2007) [30]
rs7903146 TCF7L2 10q25.3 Intron 4 T2DM 1.49 [1.39–1.59] Timpson et al., 2009 [31]
rs4402960 IGF2BP2 3q27.2 Intron 2 T2DM 1.14 [1.08–1.21] Takeuchi et al., 2009 [28]
rs5215 KCNJ11 11p15.1 Exon 1 T2DM 1.16 [1.09–1.23] Zeggini et al., 2008 [12]
rs7756992 CDKAL1 6p22.3 Intron 5 T2DM 1.20 [1.13–1.27] Steinthorsdottir et al., 2007 [32]
rs4712523 CDKAL1 6p22.3 Intron 5 T2DM 1.27 [1.21–1.33] Takeuchi et al., 2009 [28]
rs9465871 CDKAL1 6p22.3 Intron 5 T2DM 1.18 [1.04–1.34] Wellcome Trust Case Control Consortium (2007) [30]
rs7961581 nearTSPAN8/LGR5 12q21.1 Intergenic T2DM 1.09 [1.06–1.12] Zeggini et al., 2008 [12]
rs864745 JAZF1 7p15.2-p15.1 Intron 1 T2DM 1.10 [1.07–1.13] Zeggini et al., 2008 [12]
rs12779790 nearCDC123/CAMK1D 10p13 Intergenic T2DM 1.11 [1.07–1.14] Zeggini et al., 2008 [12]
rs10490072 BCL11A 2p16.1 3′ ofgene T2DM 1.05 [1.03–1.08] Zeggini et al., 2008 [12]
rs10923931 NOTCH2 1p13-p11 Intron 5 T2DM 1.13 [1.08–1.17] Zeggini et al., 2008 [12]
rs7578597 THADA 2p21 Exon 24, missense T2DM 1.15 [1.10–1.20] Zeggini et al., 2008 [12]
rs2025804 LEPR 1p31 Intron 2 BMI   Traurig et al., 2012 [33]
rs2641348 ADAM30 1p12 Exon 1, missense T2DM 1.10 [1.06–1.15] Zeggini et al., 2008 [12]
rs9472138 near VEGFA 6p21.1 Intergenic T2DM 1.06 [1.04–1.09] Zeggini et al., 2008 [12]
rs1042714 ADRB2 5q31-q32 Exon 1, missense T2DM 0.56 [0.36–0.91] Pinelli et al., 2006 [34]
rs4994 ADRB3 8p12 Exon 1, missense T2DM 1.27 [1.07–1.51] Jing et al., 2012 [35]
rs1799883 FABP2 4q28-q31 Exon 2, missense T2DM 1.29 [1.08–1.49] Qiu et al., 2014 [8]
rs1801282 PPARG 3p25 Exon 4, missense T2DM 1.14 [1.08–1.20] Scott et al., 2007 [11]
rs8192678 PPARGC1A 4p15.1 Exon 8, missense T2DM 1.07 [1.00–1.15] Barroso et al., 2006 [37]
rs780094 GCKR 2p23 Intron 16 T2DM 0.71 [0.58–0.85] Onuma et al., 2010 [38]
rs7944584 MADD 11p11.2 Intron 25 T2DM 1.63 [1.32–2.02] Hu et al., 2010 [39]
rs1153188 DCD-VDAC1P5 12q13 Intergenic T2DM 1.08 [1.05–1.11] Zeggini et al., 2008 [12]