The susceptibility of FSHB -211G > T and FSHR G-29A, 919A > G, 2039A > G polymorphisms to men infertility: an association study and meta-analysis

Table 2 Allele and genotype frequencies of the FSHR rs6165, rs6166 and rs1394205 genotypes and FSHB rs10835638 genotypes in the infertile and fertile groups

Genotype	Control (n = 340) frequency	Case (n = 255)			Sperm concentration(<5 ×10⁶/ml) (n = 166)			Sperm concentration(5–15 ×10⁶/ml) (n = 89)
Genotype	Control (n = 340) frequency	frequency	P	OR(95%CI)	frequency	P	OR(95%CI)	frequency	P	OR(95%CI)
FSHR rs6165Thr307Ala
AA	0.479	0.416	0.292	ref	0.422	0.452	ref	0.404	0.448	ref
AG	0.424	0.471	0.154	1.28(0.91–1.81)	0.464	0.269	1.25(0.84–1.85)	0.483	0.232	1.35 (0.82–2.22)
GG	0.097	0.113	0.285	1.35 (0.77–2.36)	0.114	0.355	1.35 (0.72–2.53)	0.113	0.429	1.38 (0.62–3.05)
FSHR rs6166 Asn680Ser
AA	0.497	0.475	0.466	ref	0.476	0.418	ref	0.472	0.836	ref
AG	0.429	0.424	0.842	1.04 (0.74–1.46)	0.416	0.946	1.01 (0.68–1.50)	0.438	0.770	1.08 (0.66–1.75)
GG	0.074	0.101	0.219	1.45 (0.80–2.64)	0.108	0.199	1.54 (0.80–3.00)	0.100	0.561	1.29 (0.54–3.07)
FSHR rs1394205 -29G > A
GG	0.229	0.208	0.704	ref	0.241	0.328	ref	0.146	0.136	ref
GA	0.500	0.494	0.675	1.09 (0.72–1.66)	0.434	0.427	0.83 (0.52–1.32)	0.607	0.055	1.91 (0.99–3.71)
AA	0.271	0.298	0.408	1.22 (0.76–1.93)	0.325	0.603	1.14 (0.69–1.90)	0.247	0.348	1.43 (0.68–3.04)
FSHB rs10835638 -211G > T
GG	0.935	0.929	0.993	ref	0.928	0.996	ref	0.933	-	ref
GT	0.065	0.067	0.908	1.04 (0.54–2.00)	0.066	0.930	1.03 (0.49–2.19)	0.067	0.935	1.04 (0.41–2.65)

OR odds ratio, CI confidence interval; Ref: control by heterozygous genotypes and rare homozygous

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