Fig. 3

Confirmation of novel mutation in family II. a Confirmation of autosomal recessive pattern of PLA2G6 mutation in the proband with PLAN disorder. b Comparative amino acids alignment of PLA2G6 protein across all Kingdoms. c Intrinsic disorder profile for PLA2G6 and its secondary structure map predicted by DISOPRED3. Amino acids in the input sequence are considered disordered when the dark line is above the gray dashed line, that is the confidence score is higher than 0.5