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Table 2 Interaction analyses of the HIF3A rs3826795 polymorphism and obesity on plasma ALT

From: Interaction between obesity and the Hypoxia Inducible Factor 3 Alpha Subunit rs3826795 polymorphism in relation with plasma alanine aminotransferase

 

Mean ± SD of logALT (IU/L)

   
 

AA (n = 535)

AG (n = 985)

GG (n = 468)

β’

P

P inter

Total

1.11 ± 0.27

1.12 ± 0.27

1.14 ± 0.28

0.020

0.340

 

Non-obese

1.04 ± 0.25

1.06 ± 0.23

1.05 ± 0.23

−0.009

0.741

0.042

Obese

1.24 ± 0.26

1.25 ± 0.30

1.30 ± 0.29

0.075

0.037

  1. β’ stands for the standardized coefficient of G allele number in the model
  2. P inter stands for the P value of the interaction term in the linear regression model, including logALT as the dependent variable, and SNP, obesity group, SNP × obesity group, age, age2 and gender as independent variables
  3. HIF3A: Hypoxia Inducible Factor 3 Alpha Subunit; ALT alanine aminotransferase
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BMC Medical Genetics

ISSN: 1471-2350

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