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Table 4 Final restricted maximum likelihood model, using pedigree-based measured genotype association, explaining variance in QTc in the LQT1 founder populations

From: Sex is a moderator of the association between NOS1AP sequence variants and QTc in two long QT syndrome founder populations: a pedigree-based measured genotype association analysis

Covariatesa Beta SE P-valueb
In the entire study population (n = 312)
  KCNQ1 genotype (positive) +47 3.9 2.0 × 10−13
 rs12143842 (Aa or aa) +18 5.4 0.0007
 Sex (female) +23 4.9 0.004
 Sex*rs12143842 interaction -12 6.7 0.08
 Proportion of variance explained    32%
In females (n = 180)
  KCNQ1 genotype (positive) +44 4.9 6.4 × 10−17
 Age at electrocardiogram (per year) +0.22 0.1 0.02
 Proportion of variance explained    31%
In males (n = 132)
  KCNQ1 genotype (positive) +47 6.1 5.6 × 10−11
 rs12143842 (Aa or aa) +19 6.0 0.002
 Proportion of variance explained    23%
  1. Beta- unstandardized beta coefficient (~effect size, ms), SE- standard error
  2. aInclusion criteria in final model p < 0.1 (interactions sex*KCNQ1 genotype and sex*age at electrocardiogram were excluded from all models, rs12143842 was not significantly associated with QTc in females (p = 0.16) and excluded from the final model, increasing age at electrocardiogram was significantly associated with a longer QTc in females only)
  3. bCalculated by pedigree-based measured genotype association analysis using SOLAR software (solar-eclipse-genetics.org)
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BMC Medical Genetics

ISSN: 1471-2350

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