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Table 4 Final restricted maximum likelihood model, using pedigree-based measured genotype association, explaining variance in QTc in the LQT1 founder populations

From: Sex is a moderator of the association between NOS1AP sequence variants and QTc in two long QT syndrome founder populations: a pedigree-based measured genotype association analysis

Covariatesa

Beta

SE

P-valueb

In the entire study population (n = 312)

  KCNQ1 genotype (positive)

+47

3.9

2.0 × 10−13

 rs12143842 (Aa or aa)

+18

5.4

0.0007

 Sex (female)

+23

4.9

0.004

 Sex*rs12143842 interaction

-12

6.7

0.08

 Proportion of variance explained

  

32%

In females (n = 180)

  KCNQ1 genotype (positive)

+44

4.9

6.4 × 10−17

 Age at electrocardiogram (per year)

+0.22

0.1

0.02

 Proportion of variance explained

  

31%

In males (n = 132)

  KCNQ1 genotype (positive)

+47

6.1

5.6 × 10−11

 rs12143842 (Aa or aa)

+19

6.0

0.002

 Proportion of variance explained

  

23%

  1. Beta- unstandardized beta coefficient (~effect size, ms), SE- standard error
  2. aInclusion criteria in final model p < 0.1 (interactions sex*KCNQ1 genotype and sex*age at electrocardiogram were excluded from all models, rs12143842 was not significantly associated with QTc in females (p = 0.16) and excluded from the final model, increasing age at electrocardiogram was significantly associated with a longer QTc in females only)
  3. bCalculated by pedigree-based measured genotype association analysis using SOLAR software (solar-eclipse-genetics.org)