Fig. 3From: MLPA identification of dystrophin mutations and in silico evaluation of the predicted protein in dystrophinopathy cases from IndiaTransversely cut skeletal muscle tissue shows dystrophic features on HE staining in both DMD and β- sarcoglycanopathy (Fig I & Q) as against normal muscle tissue (Fig A). Immunohistochemically, antibodies against dystrophin (dys1,2,3) and sarcoglycans (α,β,γ,δ) shows preserved expression along the membrane in all the fibres (Fig B-H) in normal muscle tissue, while total loss of expression for dystrophin (Fig J,K,L) and preserved expression for sarcoglycans (Fig M,N,O,P) indicates the diagnosis of the DMD. Note: Preserved expression of dystrophin (Fig R,S,T) and δ &γ sarcoglycans (Fig W,X) reduced α-sarcoglycan (Fig U)and complete absence of β-sarcoglycan (Fig V) in a case of b-sarcoglycanopathyBack to article page