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Fig. 3 | BMC Medical Genetics

Fig. 3

From: KCNJ11, ABCC8 and TCF7L2 polymorphisms and the response to sulfonylurea treatment in patients with type 2 diabetes: a bioinformatics assessment

Fig. 3

A schematic representation of 24 ABCC8 missense SNPs in the protein product. Each SUR1 subunit (i.e., ABCC8 protein product) contains 17 transmembrane helices, which are arranged in three transmembrane domains, i.e., TMD0, TMD1, and TMD2, respectively. The large cytosolic loop between TMD0 and TMD1 is called cytosolic loops 3 (CL3). The large cytosolic domains following TMD1 and TMD2 contain nucleotide-binding domain 1 (NBD1) and NBD2, respectively

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