Table 6 Allele and genotype frequencies in GD patients with or without family history and controls
GENE | SNP | Alleles | Con (%) | GD-FH (%) | P | GD non-FH (%) | P | P (FH/non-FH) |
|---|---|---|---|---|---|---|---|---|
Sepp1 | rs6865453 | A | 1338 (74.5) | 206 (75.18) | 0.675 | 694 (71.55) | 0.089 | 0.2517 |
C | 458 (25.5) | 68 (24.82) | 276 (28.45) | |||||
AA | 491 (54.68) | 77 (56.20) | 245 (50.52) | |||||
AC | 356 (39.64) | 52 (37.96) | 204 (42.06) | |||||
CC | 51 (5.68) | 8 (5.84) | 36 (7.42) | |||||
GPX4 | rs713041 | C | 1031 (57.41) | 151 (55.11) | 0.511 | 540 (55.67) | 0.393 | 0.8906 |
T | 765 (42.59) | 123 (44.89) | 430 (44.33) | |||||
CC | 300 (33.41) | 39 (28.47) | 155 (31.96) | |||||
CT | 431 (48) | 73 (53.28) | 230 (47.42) | |||||
TT | 167 (18.6) | 25 (18.25) | 100 (20.62) | |||||
rs2074451 | G | 1004 (55.96) | 150 (55.56) | 0.980 | 529 (55.10) | 0.680 | 0.9448 | |
T | 790 (44.04) | 120 (44.44) | 431 (44.90) | |||||
GG | 292 (31.44) | 39 (28.89) | 149 (31.04) | |||||
GT | 440 (49.05) | 72 (53.33) | 231 (48.13) | |||||
TT | 175 (19.51) | 24 (17.78) | 100 (20.83) | |||||
rs3746165 | C | 1019 (56.74) | 146 (53.28) | 0.353 | 535 (55.15) | 0.438 | 0.5833 | |
T | 777 (43.26) | 128 (46.72) | 435 (44.85) | |||||
CC | 287 (31.96) | 36 (26.28) | 150 (30.93) | |||||
CT | 445 (49.55) | 74 (50.01) | 235 (48.45) | |||||
TT | 166 (18.49) | 27 (19.71) | 100 (20.62) | |||||
SEPS1 | rs28665122 | C | 1688 (93.47) | 265 (95.32) | 0.244 | 907 (94.87) | 0.161 | 0.8764 |
T | 118 (6.53) | 13 (4.68) | 49 (5.13) | |||||
CC | 793 (87.82) | 126 (90.65) | 431 (90.17) | |||||
CT | 102 (11.3) | 13 (9.35) | 45 (9.41) | |||||
TT | 8 (0.9) | 0 (0) | 2 (0.42) | |||||
rs7178239 | G | 802 (45.57) | 119 (44.40) | 0.609 | 443 (46.83) | 0.542 | 0.4886 | |
C | 958 (54.43) | 149 (55.60) | 503 (53.17) | |||||
GG | 180 (20.45) | 27 (20.15) | 101 (21.35) | |||||
CG | 442 (50.23) | 65 (48.51) | 241 (50.95) | |||||
CC | 258 (29.32) | 42 (31.34) | 131 (27.70) |