PEAR1 is not a major susceptibility gene for cardiovascular disease in a Flemish population

BMC Medical Genetics

Table 3 Multivariable-adjusted hazard ratios by rs12566888 genotype

Event	N° of events (rate per 1000 person-years)		Hazard ratio (95% CI)	P
Event	T allele carriers (N = 363)	GG homozygotes (N = 1575)	Hazard ratio (95% CI)	P
Total mortality	40 (6.80)	198 (7.58)	0.99 (0.72–1.36)	0.95
Cardiovascular mortality	7 (1.19)	46 (1.79)	0.79 (0.36–1.73)	0.55
Cardiovascular events	27 (4.76)	154 (6.15)	0.78 (0.50–1.20)	0.25
Coronary events	18 (3.13)	89 (3.50)	0.93 (0.55–1.58)	0.79
Ischaemic cerebrovascular events	8 (1.37)	53 (2.05)	0.72 (0.35–1.46)	0.36

Numbers of events do not add up, because only the first event in each category was analysed. Hazard ratios (95% confidence interval) express the risk of minor allele carriers vs. major allele homozygotes. Hazard ratios account for family clusters, and were adjusted for baseline characteristics including sex, age, body mass index, mean arterial pressure, total-to-HDL cholesterol ratio, smoking and drinking, antihypertensive drug treatment, and history of cardiovascular disease and diabetes mellitus

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